Charak B S, Louie R, Malloy B, Twomey P, Mazumder A
Norris Cancer Hospital and Research Institute, University of Southern California, Los Angeles 90033.
J Antimicrob Chemother. 1991 Jan;27(1):95-104. doi: 10.1093/jac/27.1.95.
The effects of certain antibiotics on the colony forming activity of human bone marrow cells in semisolid methylcellulose medium in vitro and on murine BM cells in spleen colony forming units (cfu-s) in vivo were evaluated. Amikacin, gentamicin, piperacillin, co-trimoxazole and pentamidine had little or no effect on human bone marrow progenitor cell function; amphotericin B, aztreonam, ceftazidime and imipenem caused significant suppression of human colony forming unit-erythroid (cfu-e), burst forming unit-erythroid (bfu-e) and colony forming unit-granulocyte macrophage (cfu-gm) at both peak and trough serum concentrations. At molar equivalent concentrations ceftazidime, cefotaxime and cefoperazone caused significant decreases in human cfu-e, bfu-e and cfu-gm in vitro (P less than 0.01) and murine cfu-s in vivo (P less than 0.05); cefoxitin, cefuroxime, ceftizoxime and ceftriaxone did not suppress human bone marrow progenitor cell activity. Gentamicin, piperacillin and ceftriaxone had no effect on murine cfu-s formation. Further studies to evaluate the effect of these antibiotics on human bone marrow in vivo are suggested.
评估了某些抗生素对体外半固体甲基纤维素培养基中人类骨髓细胞集落形成活性以及体内脾脏集落形成单位（cfu-s）中鼠类骨髓细胞的影响。阿米卡星、庆大霉素、哌拉西林、复方新诺明和喷他脒对人类骨髓祖细胞功能几乎没有影响；两性霉素B、氨曲南、头孢他啶和亚胺培南在血清峰浓度和谷浓度时均显著抑制人类红系集落形成单位（cfu-e）、红系爆式集落形成单位（bfu-e）和粒系巨噬系集落形成单位（cfu-gm）。在摩尔等效浓度下，头孢他啶、头孢噻肟和头孢哌酮在体外显著降低人类cfu-e、bfu-e和cfu-gm（P<0.01），在体内显著降低鼠类cfu-s（P<0.05）；头孢西丁、头孢呋辛、头孢唑肟和头孢曲松不抑制人类骨髓祖细胞活性。庆大霉素、哌拉西林和头孢曲松对鼠类cfu-s形成没有影响。建议进一步研究评估这些抗生素对体内人类骨髓的影响。
