Bosnia 和 Herzegovina 图兹拉地区急性缺血性脑卒中患者的性别差异。

Sex differences in patients with acute ischemic stroke in Tuzla region, Bosnia and Herzegovina.

机构信息

Department of Neurology, University Clinical Centre, Faculty of Medicine, Trnovac bb, Tuzla, Bosnia and Herzegovina.

出版信息

Bosn J Basic Med Sci. 2010 May;10(2):116-20. doi: 10.17305/bjbms.2010.2705.

DOI:10.17305/bjbms.2010.2705

PMID:20507291

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5509396/

Abstract

Although many aspects of stroke are similar at both sexes, however, there are some differences and characteristics as well. The aim of this study was to analyze sex differences in patients with acute ischemic stroke (IS) regarding to risk factors, subtypes, stroke severity and outcome. From January 1st 2001 to December 31st 2005 at the Department of Neurology Tuzla 2833 patients were admitted with acute ischemic stroke (IS). We were analyzed risk factors, subtypes, stroke severity (Scandinavian Stroke Scale), and thirty-day outcome. There were 1484 (52.3%) female, and they were older than male (67.8 +/- 10.6 vs. 65.7 +/- 10.5, p<0.0001). Hypertension (78% vs. 67%, p<0.0001), heart diseases (50% vs. 45%, p=0.009), atrial fibrillation (22% vs. 14%, p<0.0001) and diabetes mellitus (33% vs. 21%, p<0.0001) were frequently in female, while smoking (45% vs. 14%) and alcohol overuse (18% vs. 0,6%) in male (p<0.0001). Atherothrombotic type of ischemic stroke was frequently in male (37.4% vs. 31.6%, p=0.0013) and cardioembolic in female (21.7% vs. 15.5%, p<0.0001). At admission female had lower SS (SS 31.0 +/- 15 vs. 34.0 +/- 15, p<0.0001). Thirty-day mortality was significantly higher in female (23.3% vs. 18.4%, p=0.0015), and favourable outcome within one month (Rankin Scale <or= 2) had 58% male and 51% female (p=0.001). The frequency of ischemic stroke is higher in female who are older than male. There are some sex differences according to the distribution of risk factors and subtypes of ischemic stroke. Stroke severity at admission, thirty-day mortality, and disability are higher in female.

摘要

尽管男女两性中风的许多方面相似，但也存在一些差异和特点。本研究旨在分析急性缺血性中风（IS）患者的性别差异，包括危险因素、亚型、中风严重程度和预后。2001 年 1 月 1 日至 2005 年 12 月 31 日，在图兹拉神经病学部，有 2833 例急性缺血性中风（IS）患者入院。我们分析了危险因素、亚型、中风严重程度（斯堪的纳维亚中风量表）和 30 天预后。女性患者 1484 例（52.3%），年龄大于男性（67.8 +/- 10.6 岁 vs. 65.7 +/- 10.5 岁，p<0.0001）。高血压（78% vs. 67%，p<0.0001）、心脏病（50% vs. 45%，p=0.009）、心房颤动（22% vs. 14%，p<0.0001）和糖尿病（33% vs. 21%，p<0.0001）在女性中更为常见，而吸烟（45% vs. 14%）和酗酒（18% vs. 0.6%）在男性中更为常见（p<0.0001）。动脉粥样硬化血栓形成性缺血性中风在男性中更为常见（37.4% vs. 31.6%，p=0.0013），而心源性栓塞在女性中更为常见（21.7% vs. 15.5%，p<0.0001）。入院时女性的 SS 较低（SS 31.0 +/- 15 与 34.0 +/- 15，p<0.0001）。女性 30 天死亡率显著升高（23.3% vs. 18.4%，p=0.0015），一个月内预后良好（Rankin 量表<或=2）的患者中，男性占 58%，女性占 51%（p=0.001）。女性中风发病率高于男性，且女性患者年龄大于男性。根据缺血性中风的危险因素和亚型分布，存在一些性别差异。入院时的中风严重程度、30 天死亡率和残疾在女性中更高。