Orthopedic Department, Uijeongbu St, Mary's Hospital, Kumoh-dong, Uijeongbu City, Gyeonggi-do, 480-717, Korea.
BMC Musculoskelet Disord. 2010 May 28;11:103. doi: 10.1186/1471-2474-11-103.
Gel-type autologous chondrocyte (Chondron) implantations have been used for several years without using periosteum or membrane. This study involves evaluations of the clinical results of Chondron at many clinical centers at various time points during the postoperative patient follow-up.
Data from 98 patients with articular cartilage injury of the knee joint and who underwent Chondron implantation at ten Korean hospitals between January 2005 and November 2008, were included and were divided into two groups based on the patient follow-up period, i.e. 13~24-month follow-up and greater than 25-month follow-up. The telephone Knee Society Score obtained during telephone interviews with patients, was used as the evaluation tool.
On the tKSS-A (telephone Knee Society Score-A), the score improved from 43.52 +/- 20.20 to 89.71 +/- 13.69 (P < 0.05), and on the tKSS-B (telephone Knee Society Score-B), the score improved from 50.66 +/- 20.05 to 89.38 +/- 15.76 (P < 0.05). The total improvement was from 94.18 +/- 31.43 to 179.10 +/- 24.69 (P < 0.05).
Gel-type autologous chondrocyte implantation for chondral knee defects appears to be a safe and effective method for both decreasing pain and improving knee function.
胶体型自体软骨细胞（Chondron）植入术已应用多年，无需使用骨膜或膜。本研究涉及在术后患者随访的不同时间点，在多个临床中心对 Chondron 的临床结果进行评估。
纳入了 2005 年 1 月至 2008 年 11 月在韩国的 10 家医院接受 Chondron 植入术的 98 例膝关节软骨损伤患者的数据，并根据患者随访时间分为两组，即 13~24 个月随访组和大于 25 个月随访组。使用电话访谈中患者的膝关节协会评分（Knee Society Score，KSS）作为评估工具。
在电话膝关节协会评分（KSS）-A 中，评分从 43.52 +/- 20.20 提高到 89.71 +/- 13.69（P < 0.05），在电话膝关节协会评分（KSS）-B 中，评分从 50.66 +/- 20.05 提高到 89.38 +/- 15.76（P < 0.05）。总改善率从 94.18 +/- 31.43 提高到 179.10 +/- 24.69（P < 0.05）。
胶体型自体软骨细胞植入治疗软骨膝关节缺损似乎是一种安全有效的方法，可减轻疼痛并改善膝关节功能。
