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三位一体的进展:间充质干细胞同种异体移植在足踝外科手术中的应用

Trinity Evolution: mesenchymal stem cell allografting in foot and ankle surgery.

作者信息

Rush Shannon M

机构信息

Department of Podiatric Surgery, Palo Alto Medical Foundation, Mountain View, California, USA.

出版信息

Foot Ankle Spec. 2010 Jun;3(3):140-3. doi: 10.1177/1938640010369638.

DOI:10.1177/1938640010369638
PMID:20508015
Abstract

Biologic augmentation of orthopaedic procedures is a time-tested useful adjunct. The ability to predictably heal all fractures and arthrodesis procedures is still elusive because of multiple factors. The next frontier in musculoskeletal medicine and surgery will involve increasing biologic manipulation of the healing environment. Mesenchymal stem cell allograft is viable living biologic material that is capable of new bone formation and osteointegration at the implantation site.

摘要

骨科手术的生物增强是一种经过时间考验的有用辅助手段。由于多种因素,可预测地治愈所有骨折和关节融合手术的能力仍然难以实现。肌肉骨骼医学和外科的下一个前沿领域将涉及对愈合环境进行更多的生物操控。间充质干细胞同种异体移植物是一种有活力的生物材料,能够在植入部位形成新骨并实现骨整合。

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Prospective clinical and radiographic evaluation of an allogeneic bone matrix containing stem cells (Trinity Evolution® Viable Cellular Bone Matrix) in patients undergoing two-level anterior cervical discectomy and fusion.
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J Orthop Surg Res. 2017 Apr 26;12(1):67. doi: 10.1186/s13018-017-0564-5.
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Plastic Surgery Challenges in War Wounded II: Regenerative Medicine.战争伤员的整形手术挑战II:再生医学
Adv Wound Care (New Rochelle). 2016 Sep 1;5(9):412-419. doi: 10.1089/wound.2015.0655.
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Clinical evaluation of an allogeneic bone matrix containing viable osteogenic cells in patients undergoing one- and two-level posterolateral lumbar arthrodesis with decompressive laminectomy.对接受一期和二期后路腰椎椎间融合术并减压椎板切除术患者使用含活性成骨细胞的同种异体骨基质的临床评估。
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A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolution™) with a comparison to historical controls.一项针对有症状的颈椎退行性椎间盘疾病患者进行单节段颈椎前路椎间盘切除融合术的前瞻性临床和影像学12个月结局研究,使用一种新型的活性同种异体松质骨基质(Trinity Evolution™),并与历史对照进行比较。
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Current concepts: tissue engineering and regenerative medicine applications in the ankle joint.当前概念:踝关节组织工程和再生医学的应用。
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