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酵母II型肌球蛋白重链：对其预测的多肽序列的分析。

The yeast type II myosin heavy chain: analysis of its predicted polypeptide sequence.

作者信息

Sweeney F P, Pocklington M J, Orr E

机构信息

Department of Genetics, University of Leicester, UK.

出版信息

J Muscle Res Cell Motil. 1991 Feb;12(1):61-8. doi: 10.1007/BF01781175.

DOI:10.1007/BF01781175
PMID:2050812
Abstract

We have completed the nucleotide sequence of the yeast MYO1 gene and deduced its amino acid sequence. The gene is 5553 bp long and contains no introns. Analysis of the sequence, as well as its comparison with other myosins, demonstrate that the yeast protein is a type II myosin heavy chain with characteristic head and tail regions. The latter domain contains six proline residues in two clusters of three, at approximately two thirds from the start of the gene.

摘要

我们已完成酵母MYO1基因的核苷酸序列测定，并推导了其氨基酸序列。该基因长5553 bp，无内含子。对该序列的分析及其与其他肌球蛋白的比较表明，酵母蛋白是一种具有特征性头部和尾部区域的II型肌球蛋白重链。后一个结构域在距基因起始约三分之二处的两个三聚体簇中含有六个脯氨酸残基。

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本文引用的文献

1
Isolation and characterization of the actin gene from Tetrahymena thermophila.从嗜热四膜虫中分离和鉴定肌动蛋白基因。
Proc Natl Acad Sci U S A. 1986 Jul;83(14):5160-4. doi: 10.1073/pnas.83.14.5160.
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An actin-binding site on the 20K fragment of myosin subfragment 1.肌球蛋白亚片段1的20K片段上的一个肌动蛋白结合位点。
Biochemistry. 1982 Sep 14;21(19):4800-4. doi: 10.1021/bi00262a043.
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Structure of rabbit skeletal myosin. Analysis of the amino acid sequences of two fragments from the rod region.兔骨骼肌肌球蛋白的结构。杆状区域两个片段的氨基酸序列分析。
由myo2基因编码的II型肌球蛋白重链在粟酒裂殖酵母的胞质分裂过程中组成收缩环。
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4
Potentially rapid walking in cellular regulatory networks using the gene-gene interference method in yeast.利用酵母中的基因-基因干扰方法在细胞调控网络中实现潜在的快速运作
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Cloning and characterization of PAS5: a gene required for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris.PAS5的克隆与特性分析：甲基营养型酵母毕赤酵母中过氧化物酶体生物发生所需的一个基因
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6
par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.PAR-2是秀丽隐杆线虫中卵裂球不对称所必需的一种基因，它编码锌指和ATP结合基序。
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6108-12. doi: 10.1073/pnas.91.13.6108.
J Mol Biol. 1981 Dec 5;153(2):459-64. doi: 10.1016/0022-2836(81)90290-4.
4
Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.秀丽隐杆线虫unc-54肌球蛋白重链基因中的蛋白质结构域未被内含子隔开。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4253-7. doi: 10.1073/pnas.80.14.4253.
5
Periodic features in the amino acid sequence of nematode myosin rod.线虫肌球蛋白杆状区氨基酸序列中的周期性特征。
J Mol Biol. 1983 Mar 15;164(4):605-26. doi: 10.1016/0022-2836(83)90053-0.
6
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Nucleic Acids Res. 1981 Jan 24;9(2):309-21. doi: 10.1093/nar/9.2.309.
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J Biol Chem. 1973 Jul 10;248(13):4682-90.
10
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DNA. 1985 Apr;4(2):165-70. doi: 10.1089/dna.1985.4.165.