SDSU/UCSD Joint Doctoral Program in Clinical Psychology, University of California-San Diego, San Diego, CA 92093-0733, USA.
Support Care Cancer. 2011 Aug;19(8):1107-15. doi: 10.1007/s00520-010-0914-x. Epub 2010 May 29.
The goal of this study was to examine the relationship between menopausal symptoms, sleep quality, and mood as measured by actigraphy and self-report prior to treatment and at the end of four cycles of chemotherapy in women with breast cancer.
Data on sleep quality (measured using actigraphy and self-report) and mood were collected prior to treatment and 12 weeks later at the end of four cycles of chemotherapy in 69 women with newly diagnosed breast cancer. In addition, each filled out the Greene Climacteric Scale. Based on reported occurrence of menses, participants were categorized post hoc into three menopausal status groups: pre-menopausal before and after chemotherapy (Pre-Pre), pre-menopausal or peri-menopausal before and peri-menopausal after chemotherapy (Pre/Peri-Peri), and post-menopausal before and after chemotherapy (Post-Post).
Results suggested that women within the Pre-Pre group evidenced more fragmented sleep with less total sleep time (TST) after chemotherapy compared to baseline. Compared to the other groups, the Pre-Pre group also experienced less TST and more awakenings before and after chemotherapy. Although the Pre/Peri-Peri group evidenced a greater increase in vasomotor symptoms after chemotherapy, there was no relationship with sleep. All groups evidenced more depressive symptoms after chemotherapy, but depression was not related to measures of sleep.
Contrary to the study hypothesis, these results suggest that women who are pre-menopausal or having regular menses before and after four cycles of chemotherapy have worse sleep following chemotherapy. Those women who maintain or become peri-menopausal (irregular menses) experience an increase in climacteric symptoms but do not experience an associated worsening of sleep. These results are preliminary and more research is necessary to further explain these findings.
本研究旨在探讨绝经症状、睡眠质量和情绪之间的关系，这些通过活动记录仪和自我报告在乳腺癌女性接受治疗前和化疗四个周期结束时进行测量。
在 69 名新诊断为乳腺癌的女性中，在接受治疗前和化疗四个周期结束后 12 周，收集睡眠质量（通过活动记录仪和自我报告测量）和情绪数据。此外，每位患者都填写了格林绝经量表。根据报告的月经情况，参与者事后被分为三个绝经状态组：化疗前后的绝经前（Pre-Pre）、化疗前后的绝经前或围绝经期（Pre/Peri-Peri）和化疗前后的绝经后（Post-Post）。
结果表明，与基线相比，化疗后 Pre-Pre 组的睡眠碎片化更严重，总睡眠时间（TST）更少。与其他组相比，Pre-Pre 组在化疗前后的 TST 更短，觉醒次数更多。尽管 Pre/Peri-Peri 组在化疗后血管舒缩症状增加更多，但与睡眠无关。所有组在化疗后都出现更多的抑郁症状，但抑郁与睡眠测量无关。
与研究假设相反，这些结果表明，在接受四个周期化疗前后处于绝经前或有规律月经的女性在化疗后睡眠质量更差。那些保持或进入围绝经期（不规律月经）的女性经历更多的更年期症状，但不会出现睡眠质量恶化的相关情况。这些结果是初步的，需要进一步的研究来进一步解释这些发现。
