多药联合化疗时代前后麻风分枝杆菌对利福平耐药性及对氨苯砜耐药性的比较研究

Study of rifampicin resistance and comparison of dapsone resistance of M. leprae in pre- and post-MDT era.

作者信息

Gupta U D, Katoch K, Katoch V M

机构信息

Animal Experiment Facility, National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Tajganj, Agra-282 001, India.

出版信息

Indian J Lepr. 2009 Jul-Sep;81(3):131-4.

PMID:20509341

Abstract

The aim of this study to study the drug resistance patterns of dapsone (pre- and post-MDT) and rifampicin (post-MDT era). All the 84 patients from pre-MDT period (1985-1990) and 77 patients for post-MDT period (1990-2002) reporting to a tertiary care hospital-NJIL & OMD, Agra and referred for drug susceptibility testing were included in the study. Drug resistance was studied by mouse foot pad method. Dapsone resistance was high during pre-MDT era i.e. 8.3% (medium) and 19.1% (high) with an overall dapsone resistance of 27.4%. During the post-MDT era, the dapsone resistance was low i.e. 1.3% (medium) and 3.9% (high) respectively (overall dapsone resistance-5.2%). While no comparison with pre-MDT era is available, the rifampicin resistance in these selected self-reporting cases during the post-MDT era was comparatively rather high (9.1%). MDT appears to have been useful in reducing the prevalence of dapsone resistance in leprosy patients reporting to a tertiary care hospital.

摘要

本研究旨在探讨氨苯砜（MDT 前后）和利福平（MDT 时代后）的耐药模式。所有向阿格拉的三级护理医院 NJIL & OMD 报告并被转诊进行药敏试验的 84 例 MDT 前时期（1985 - 1990 年）患者和 77 例 MDT 后时期（1990 - 2002 年）患者被纳入研究。采用小鼠足垫法研究耐药性。在 MDT 前时代，氨苯砜耐药性较高，即中度耐药为 8.3%，高度耐药为 19.1%，氨苯砜总体耐药率为 27.4%。在 MDT 后时代，氨苯砜耐药性较低，分别为中度耐药 1.3%和高度耐药 3.9%（氨苯砜总体耐药率 - 5.2%）。虽然无法与 MDT 前时代进行比较，但在这些选定的自我报告病例中，MDT 后时代的利福平耐药性相对较高（9.1%）。MDT 似乎有助于降低向三级护理医院报告的麻风病患者中氨苯砜耐药性的流行率。