分子流行病学方法检测到的耐氨苯砜麻风病传播。
Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.
机构信息
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
Antimicrob Agents Chemother. 2011 Nov;55(11):5384-7. doi: 10.1128/AAC.05236-11. Epub 2011 Aug 22.
Abstract
Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.
摘要
耐药性监测在菲律宾发现了 6 例未经治疗的麻风病患者，他们的麻风分枝杆菌 folP1 突变可导致对氨苯砜的耐药性。5 名患者居住在同一个村庄；携带突变体 Thr53Val 的 4 人还与麻风分枝杆菌可变数目串联重复（VNTR）菌株类型相关。在印度，两名有氨苯砜治疗史的复发患者中检测到 folP1 突变。利福平靶基因 rpoB 中未发现突变。这些发现表明氨苯砜耐药性正在传播。
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