Yang Chen, Guo Zhi-rong, Hu Xiao-shu, Zhou Zheng-yuan, Wu Ming, Yu Hao, Zhang Li-jun
Department of Radiology & Public Health, Soochow University, Suzhou 215123, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Mar;31(3):260-3.
To investigate the relationship on the effect of blood pressure (BP) control and the incidence of new diabetes mellitus (DM) in a follow-up study.
In this prospective study, non-diabetic subjects (n = 3146, 41% men) were recruited from the program "Prevention of Multiple Metabolic disorders and metabolic syndrome (MS) in Jiangsu province" (PMMJS) to evaluate the risk of DM in relation to BP control program on both healthy or hypertensive patients.
During the follow-up period, 102 subjects developed diabetes. In both healthy or hypertensive patients groupes, the incidence rates of diabetes increased along with the increase of either systolic or diastolic BP and were significantly higher in subjects who had become hypertension (5.6%) or patients with uncontrolled (7.1%) BP at baseline survey than in those who had maintained normal BP (1.9%) or with controlled BP at baseline survey (2.2%). After adjusted for age, sex and other diabetes-related risk factors at baseline study, the aRR of diabetes incidence for subjects with normal BP at baseline who became hypertension (1.84, 95%CI: 1.00 - 3.63) was higher than who maintained normal BP (1.90, 95%CI: 1.03 - 3.74) after the follow-up program, and hypertensive patients with uncontrolled BP was higher than those with controlled BP. When adjusted for baseline MS, the aRR (95%CI) for subjects with normal BP at baseline who had developed hypertension was 1.70 (0.99 - 2.78) compared those remained normal BP levels after the follow-up program, and 1.90 (1.04 - 3.75) for hypertensive patients with uncontrolled BP when compared with those whose BP had been under control.
When the BP level had been effectively under control, the risk of developing a type 2 diabetes could be reduced.
在一项随访研究中调查血压（BP）控制效果与新发糖尿病（DM）发病率之间的关系。
在这项前瞻性研究中，从“江苏省多种代谢紊乱和代谢综合征（MS）预防”（PMMJS）项目中招募了非糖尿病受试者（n = 3146，41%为男性），以评估健康或高血压患者中与血压控制方案相关的糖尿病风险。
在随访期间，102名受试者患糖尿病。在健康或高血压患者组中，糖尿病发病率均随收缩压或舒张压的升高而增加，并且在基线调查时已患高血压（5.6%）或血压未得到控制（7.1%）的受试者中显著高于基线调查时血压维持正常（1.9%）或血压得到控制（2.2%）的受试者。在对基线研究时的年龄、性别和其他糖尿病相关风险因素进行校正后，随访方案后基线血压正常但后来患高血压的受试者糖尿病发病的调整风险比（aRR）（1.84，95%置信区间：1.00 - 3.63）高于血压维持正常的受试者（1.90，95%置信区间：1.03 - 3.74），血压未得到控制的高血压患者高于血压得到控制的患者。当对基线MS进行校正后，随访方案后基线血压正常但后来患高血压的受试者的aRR（95%置信区间）为1.70（0.99 - 2.78），而血压维持正常水平的受试者为1.70（0.99 - 2.78），血压未得到控制的高血压患者与血压得到控制的患者相比为1.90（1.04 - 3.75）。
当血压水平得到有效控制时，可降低患2型糖尿病的风险。
