类风湿关节炎滑膜中的细胞-细胞相互作用。
Cell-cell interactions in rheumatoid arthritis synovium.
机构信息
Division of Rheumatology and Rheumatic Diseases Research Core Center, 3918 Taubman Center, 1500 East Medical Center Drive, The University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Rheum Dis Clin North Am. 2010 May;36(2):311-23. doi: 10.1016/j.rdc.2010.02.004.
Abstract
Understanding the pathogenesis of joint inflammation and destruction in rheumatoid arthritis involves dissection of the cellular and molecular interactions that occur in synovial tissue. Development of effective targeted therapies has been based on progress in achieving such insights. Safer and more specific approaches to treatment could flow from discovery of cell-cell interaction pathways that are specific to inflammation of the joint and less important in the defense against systemic infection. This article highlights selected cell-cell interactions in rheumatoid arthritis synovium that may be worthy of evaluation as future therapeutic targets.
摘要
了解类风湿关节炎关节炎症和破坏的发病机制需要剖析滑膜组织中发生的细胞和分子相互作用。有效的靶向治疗的发展是基于取得这些认识的进展。如果发现关节炎症中特有的、而在全身性感染防御中不太重要的细胞间相互作用途径，那么治疗方法就会更安全、更具特异性。本文重点介绍了类风湿关节炎滑膜中可能值得作为未来治疗靶点进行评估的一些细胞间相互作用。
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