显示局部注射 5-氨基酮戊酸（ALA）并预先用 CO2 激光分割预处理后的手掌皮肤区域中的原卟啉 IX（PpIX）。
Demonstration of protoporphyrin IX (PpIX) localized to areas of palmar skin injected with 5-aminolevulinic acid (ALA) and pre-treated with a fractionated CO2 laser prior to topically applied ALA.
机构信息
Department of Dermatology, Naval Medical Center San Diego, San Diego, CA 92134, USA.
出版信息
Photodiagnosis Photodyn Ther. 2010 Jun;7(2):120-2. doi: 10.1016/j.pdpdt.2010.02.004. Epub 2010 Mar 27.
BACKGROUND
Several techniques designed to enhance ALA delivery into subcorneal layers of palmar skin are described.
METHODS
Six palms from three subjects were treated with topical ALA, iontophoresis enhanced delivery of ALA, intradermal injections of ALA solution, or fractionated CO(2) laser (with or without erbium:YAG surface ablation). The relative efficacy of each technique was determined using Wood's lamp illumination for the presence of fluorescent PpIX.
RESULTS
Palms treated with topically applied ALA alone or with iontophoresis pre-treatment failed to exhibit fluorescence. The palm treated with intradermal injections of ALA and the palms pre-treated with fractionated CO(2) laser with or without erbium:YAG laser surface ablation exhibited fluorescence at treatment areas.
CONCLUSION
Both intradermal injections and fractionated CO(2) laser (with or without erbium:YAG laser pre-treatment) may provide an effective means for delivery of ALA into subcorneal layers of palmar skin. Numerous potential clinical applications of these techniques (including treatment of localized palmar hyperhidrosis) exist.
背景
有几种旨在增强 ALA 递送至手掌皮下角质层的技术已被描述。
方法
对 3 名受试者的 6 只手掌分别进行了局部外用 ALA、离子电渗增强 ALA 传递、ALA 溶液皮内注射或分批次 CO2 激光（联合或不联合铒：YAG 表面消融）治疗。采用伍德灯照射以评估荧光性 PpIX 的存在来确定每种技术的相对疗效。
结果
单独使用局部外用 ALA 或离子电渗预处理的手掌均未出现荧光。接受皮内注射 ALA 治疗的手掌以及接受分批次 CO2 激光（联合或不联合铒：YAG 激光表面消融预处理）治疗的手掌在治疗区域出现荧光。
结论
皮内注射和分批次 CO2 激光（联合或不联合铒：YAG 激光预处理）都可能是将 ALA 递送至手掌皮下角质层的有效手段。这些技术有许多潜在的临床应用（包括治疗局部手掌多汗症）。
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