Laboratory of Applied Molecular Biology and Immunology, Tlemcen Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria.
Clin Biochem. 2010 Aug;43(12):942-7. doi: 10.1016/j.clinbiochem.2010.05.012. Epub 2010 May 27.
To show that lipid and lipoprotein levels and cell sodium and potassium content and transport could change depending on the degree of hypertension.
Forty-three hypertensive patients and 20 healthy subjects were recruited at the Cardiology and Biochemistry Departments of Tlemcen University Hospital Centre (Northwest of Algeria).
Levels of CHOL, TG, PL, HDL-TG, LDLc, LDL-TG, LDL-PL, HDL2-TG and HDL3-TG were significantly higher in hypertensive patients than those in controls. HDL-PL levels were significantly lower in patients compared with controls and decreased according to the grade of hypertension. HDL2c, HDL2-PL and HDL3-TG and cell content and fluxes of sodium and potassium change gradually with higher grades of hypertension.
Hypertensive patients with circulating lipid alterations are associated to ion cell content and transport abnormalities, which were worsened progressively with higher grade of hypertension.
表明血脂和脂蛋白水平以及细胞钠、钾含量和转运可能会随高血压程度的不同而发生变化。
在阿尔及利亚西北部的特莱姆森大学医院中心的心脏病学和生物化学系，招募了 43 名高血压患者和 20 名健康受试者。
与对照组相比，高血压患者的 CHOL、TG、PL、HDL-TG、LDLc、LDL-TG、LDL-PL、HDL2-TG 和 HDL3-TG 水平显著升高。与对照组相比，患者的 HDL-PL 水平显著降低，并随高血压程度的增加而降低。HDL2c、HDL2-PL 和 HDL3-TG 以及细胞内钠、钾含量和通量随着高血压程度的增加而逐渐变化。
患有血脂异常的高血压患者与细胞内离子含量和转运异常有关，且随着高血压程度的加重而逐渐恶化。
