Capitani Eduardo Mello de, Hirano Elcio Shiyoti, Zuim Isabela de Souza Cortez, Bertanha Laura, Vieira Ronan José, Madureira Paulo Roberto, Bucaretchi Fábio
Poison Control Center, School of Medicine, University Hospital, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
Sao Paulo Med J. 2009 Nov;127(6):379-81. doi: 10.1590/s1516-31802009000600011.
Hydrofluoric acid (HF) is widely used in industry and at home. Severe lesions can occur after contact with highly concentrated solutions, leading to tissue necrosis and bone destruction. Specific treatment is based on neutralization of fluoride ions with calcium or magnesium solutions.
A 41-year-old male was seen at the emergency department 35 minutes after skin contact with 70% HF, showing whitened swollen lesions on the middle and fourth fingers of his right hand with severe pain starting immediately after contact. 2.5% calcium gluconate ointment was applied. Twenty-four hours later, the patient was still in severe pain and the lesions had worsened. Considering the high concentration of the solution, early start of severe pain, lesion characteristics and impossibility of administering calcium gluconate subcutaneously because of the lesion location, the radial artery was catheterized and 2% calcium gluconate was administered via infusion pump for 36 hours, until the pain subsided. No adverse effects were seen during the procedure. Ten days later, the lesions were stable, without bone abnormalities on X-rays. Six months later, a complete recovery was seen.
Intra-arterial calcium gluconate might be considered for finger burns caused by concentrated HF. Complete recovery of wounded fingers can be achieved with this technique even if started 24 hours after the exposure. However, controlled clinical trials are needed to confirm the effectiveness and safety of this intervention.
氢氟酸(HF)在工业和家庭中广泛使用。接触高浓度溶液后可发生严重损伤,导致组织坏死和骨质破坏。特异性治疗基于用钙或镁溶液中和氟离子。
一名41岁男性在皮肤接触70%氢氟酸35分钟后被送至急诊科,其右手中指和无名指出现发白肿胀的损伤,接触后立即开始剧痛。涂抹了2.5%的葡萄糖酸钙软膏。24小时后,患者仍剧痛,损伤加重。考虑到溶液浓度高、疼痛起始早、损伤特征以及因损伤部位无法皮下注射葡萄糖酸钙,经桡动脉插管,通过输液泵输注2%葡萄糖酸钙36小时,直至疼痛缓解。过程中未观察到不良反应。10天后,损伤稳定,X线检查无骨质异常。6个月后,完全恢复。
对于因高浓度氢氟酸导致的手指烧伤,可考虑动脉内注射葡萄糖酸钙。即使在接触24小时后开始使用该技术,受伤手指也可实现完全恢复。然而,需要进行对照临床试验以证实该干预措施的有效性和安全性。