Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-C24, Cincinnati, OH 45226, USA.
Int J Behav Med. 2010 Sep;17(3):234-42. doi: 10.1007/s12529-010-9102-0.
Although self-rated health (SRH) has been established as a robust predictor of morbidity and mortality, the immunological mechanisms underpinning this relationship are poorly understood.
This study examined the association of SRH with humoral and cellular immune markers in healthy individuals who reported no physical illnesses.
A total of 116 healthy Japanese white-collar employees (79 women and 37 men) at a pharmaceutical company, aged 23-62 (mean 32) years, underwent a blood draw for the measurement of circulating immune (T, B, and natural killer) cells, inflammatory cytokines (interleukin-6 and tumor necrosis factor-alpha), and plasma immunoglobulin G (IgG) and completed a health survey including SRH. The question regarding SRH ranged from "very good" (coded 1) to "very poor" (coded 5). Hierarchical multiple regression analysis was carried out to calculate the relationship between SRH and immune markers.
In this sample, poor SRH was positively correlated with B (CD19(+)) cell numbers (beta = 0.260, p < 0.05) and IgG levels (beta = 0.335, p < 0.01) even after adjusting for depressive symptoms, age, education, marital status, smoking, alcohol consumption, physical activity, body mass index, sex, and sex x SRH interaction. The interaction between SRH and sex on the immune markers was not significant.
Although the connection between SRH and immune markers was not strong in this context, the results suggest that poor SRH may be associated with reduced humoral immune system capacity to respond to new/latent challenges. The results provide some support for the immunological basis of SRH in healthier individuals.
尽管自评健康（SRH）已被确立为发病率和死亡率的有力预测指标，但支撑这种关系的免疫机制仍知之甚少。
本研究在报告无身体疾病的健康个体中，检查了 SRH 与体液和细胞免疫标志物的相关性。
一家制药公司的 116 名健康的日本白领员工（79 名女性和 37 名男性），年龄 23-62 岁（平均 32 岁），接受了血液检查，以测量循环免疫（T、B 和自然杀伤）细胞、炎症细胞因子（白细胞介素-6 和肿瘤坏死因子-α）和血浆免疫球蛋白 G（IgG），并完成了包括 SRH 的健康调查。关于 SRH 的问题范围从“非常好”（编码为 1）到“非常差”（编码为 5）。进行了层次多重回归分析，以计算 SRH 与免疫标志物之间的关系。
在该样本中，较差的 SRH 与 B（CD19(+)）细胞数量呈正相关（β=0.260，p<0.05）和 IgG 水平（β=0.335，p<0.01），即使在调整了抑郁症状、年龄、教育程度、婚姻状况、吸烟、饮酒、身体活动、体重指数、性别和性别与 SRH 的交互作用后也是如此。SRH 与免疫标志物之间的交互作用不显著。
尽管在这种情况下，SRH 与免疫标志物之间的联系并不强，但结果表明，较差的 SRH 可能与对新/潜在挑战的体液免疫系统响应能力降低有关。结果为 SRH 在更健康个体中的免疫学基础提供了一些支持。
