免疫健康与全身炎症唾液生物标志物之间的关系。
The relationship between immune fitness and saliva biomarkers of systemic inflammation.
作者信息
Mulder Kiki Ew, van Oostrom Evi C, Verheul Marjolijn Ce, Hendriksen Pauline A, Thijssen Suzan, Diks Mara Ap, Kraneveld Aletta D, Garssen Johan, Verster Joris C
机构信息
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG, Utrecht, the Netherlands.
Global Centre of Excellence Immunology, Nutricia Danone Research, 3584CT, Utrecht, the Netherlands.
出版信息
Brain Behav Immun Health. 2023 Jun 30;31:100660. doi: 10.1016/j.bbih.2023.100660. eCollection 2023 Aug.
PURPOSE
It is vital that Immune fitness, i.e., how well the immune system functions and reacts to challenges, can be reliably be examined. The current study aimed to compare immune fitness with assessments of saliva biomarkers of systemic inflammation.
METHODS
N = 108 healthy young adults (18-30-year-old students of Utrecht University, the Netherlands) participated in the study. A saliva sample was collected for biomarker assessment (Interleukin (IL)-1β, IL-6, IL-8, IL-10, immunoglobulin A (IgA), and tumor necrosis factor-alpha (TNF-α), and c-reactive protein (CRP). Additionally, a survey was completed to assess immune fitness, mood, mental resilience, and quality of life. The correlations between the biomarker assessments, immune fitness and mood were determined.
RESULTS
No significant correlations between immune fitness and biomarkers of systemic inflammation were found. Significant sex differences in correlations with immune fitness were demonstrated for loneliness (significant only in men) and fatigue (significant only in women). For both sexes, immune fitness correlated significantly with anxiety, mental resilience, and quality of life.
CONCLUSION
No significant correlations were found between immune fitness and saliva biomarkers of systemic inflammation. Immune fitness correlated significantly with anxiety, mental resilience, and quality of life. Sex differences were demonstrated in the relation of immune fitness with loneliness and fatigue. Future research should further investigate factors that may influence the relationship between immune fitness, mood, and biomarkers of systemic inflammation, including underlying psychological mechanisms of possible sex differences.
目的
可靠地检测免疫适应性至关重要，即免疫系统的功能以及对挑战的反应情况。当前研究旨在将免疫适应性与全身炎症的唾液生物标志物评估进行比较。
方法
N = 108名健康的年轻成年人（荷兰乌得勒支大学18 - 30岁的学生）参与了该研究。采集唾液样本用于生物标志物评估（白细胞介素（IL）-1β、IL-6、IL-8、IL-10、免疫球蛋白A（IgA）、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP））。此外，还完成了一项调查以评估免疫适应性、情绪、心理韧性和生活质量。确定了生物标志物评估、免疫适应性和情绪之间的相关性。
结果
未发现免疫适应性与全身炎症生物标志物之间存在显著相关性。在与免疫适应性的相关性方面，孤独感（仅在男性中显著）和疲劳感（仅在女性中显著）存在显著的性别差异。对于男女两性而言，免疫适应性与焦虑、心理韧性和生活质量均显著相关。
结论
未发现免疫适应性与全身炎症的唾液生物标志物之间存在显著相关性。免疫适应性与焦虑、心理韧性和生活质量显著相关。在免疫适应性与孤独感和疲劳感的关系中存在性别差异。未来的研究应进一步调查可能影响免疫适应性、情绪和全身炎症生物标志物之间关系的因素，包括可能的性别差异的潜在心理机制。
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