Inoue Yukiko, Nakata Akinori, Kurioka Sumiko, Nagata Tomohisa, Mori Koji
Graduate School of Medicine, International University of Health and Welfare.
Institutional Research Center, University of Occupational and Environmental Health, Japan.
Sangyo Eiseigaku Zasshi. 2021 Jul 25;63(4):117-128. doi: 10.1539/sangyoeisei.2020-020-B. Epub 2020 Oct 22.
Although self-rated health (SRH), the self-evaluation of one's own health status, has been reported to be associated with the immune status, the relationship between three different SRH measures (global, self-comparative, and age-comparative) with inflammatory markers as well as the relative strength of these associations by age are not well understood. The current study investigated the associations between SRH measures and inflammatory markers among nursing home employees.
A sample of 120 Japanese employees at a nursing home (90 women and 30 men), aged 21-68 years (mean, 40.9 years), underwent a blood test for the measurement of inflammatory markers (interferon-γ, interleukin [IL]-4, IL-6, and tumor necrosis factor [TNF]-α, white blood cell count) and SRH during the annual health checkup. Multiple regression analysis adjusted for covariates was performed to analyze the relationship between inflammatory markers and SRH measures stratified by age, that is, aged < 40 years (younger age group) and 40 years and over (older age group).
Among the participants aged 40 years and over, poor global SRH was significantly associated with an increase in IL-6, while poor age-comparative SRH was significantly associated with an increase in TNF-α among participants aged < 40 years in the fully adjusted model controlling for potential confounders. Age-comparative SRH was also significantly associated with an increase in IL-6 among all participants. Self-comparative SRH was not significantly associated with inflammatory markers.
Our results suggest that three SRH measures are not equivalently associated with inflammatory markers, especially when the analyses were performed separately for the younger and older populations. This implies that not only differences in forms of SRH but also in age modify the relationship between SRH and inflammatory markers.
尽管自评健康状况（SRH），即对自身健康状况的自我评估，已被报道与免疫状态相关，但三种不同的SRH测量方法（整体、自我比较和年龄比较）与炎症标志物之间的关系以及这些关联在不同年龄组中的相对强度尚未得到充分了解。本研究调查了养老院员工中SRH测量方法与炎症标志物之间的关联。
在年度健康检查期间，对一家养老院的120名日本员工（90名女性和30名男性）进行了抽样，他们的年龄在21 - 68岁之间（平均年龄40.9岁），接受了血液检测以测量炎症标志物（干扰素-γ、白细胞介素[IL]-4、IL-6和肿瘤坏死因子[TNF]-α、白细胞计数）和SRH。对协变量进行调整后进行多元回归分析，以分析炎症标志物与按年龄分层的SRH测量方法之间的关系，即年龄<40岁（较年轻年龄组）和40岁及以上（较年长年龄组）。
在40岁及以上的参与者中，在控制潜在混杂因素的完全调整模型中，整体SRH较差与IL-6升高显著相关，而在年龄<40岁的参与者中，年龄比较SRH较差与TNF-α升高显著相关。在所有参与者中，年龄比较SRH也与IL-6升高显著相关。自我比较SRH与炎症标志物无显著关联。
我们的结果表明，三种SRH测量方法与炎症标志物的关联并不等同，尤其是在对年轻和年长人群分别进行分析时。这意味着不仅SRH形式的差异，而且年龄也会改变SRH与炎症标志物之间的关系。
