Munday J S, French A F, MacNamara A R
Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.
N Z Vet J. 2010 Jun;58(3):168-71. doi: 10.1080/00480169.2010.67519.
Ovariohysterectomy was performed on an adult Cavalier King Charles Spaniel. The skin that had been clipped for surgery was noticed to be erythematous 8 days later.
Poorly defined patches containing multiple papules were visible bilaterally within the clipped skin. These became larger over the following 2 weeks, and samples were collected for histology. Seven days later, the lesions were multiple raised masses, up to 5 cm in diameter. Histology revealed numerous cup-shaped epidermal proliferations extending into the dermis. The presence of keratinocytes with increased quantities of blue-grey cytoplasm, and koilocytosis suggested papillomaviral infection; Canis familiaris papillomavirus (CfPV-2) DNA was amplified from two separate samples. Complete regression was observed 8 weeks after the lesions had been initially observed.
Multiple inverted papilloma confined to skin that had been clipped for surgery.
This is the first time that the development of canine cutaneous papillomas has been associated with surgery. The nature of the association between surgery and development of the papillomas is uncertain. However, it is possible that damage to superficial skin could promote the formation of papillomas. This is the first identification of CfPV-2 in New Zealand.
对一只成年骑士查理王小猎犬实施了卵巢子宫切除术。术后8天，发现手术部位的皮肤发红。
在手术部位的皮肤两侧可见边界不清的斑片，斑片内有多个丘疹。在接下来的2周内，这些丘疹变得更大，随后采集样本进行组织学检查。7天后，病变发展为多个隆起的肿物，直径达5厘米。组织学检查显示有大量杯状表皮增生并延伸至真皮层。角质形成细胞的蓝灰色细胞质增多以及出现空泡化提示乳头瘤病毒感染；从两份独立样本中扩增出犬乳头瘤病毒（CfPV-2）DNA。在最初发现病变8周后观察到病变完全消退。
局限于手术部位皮肤的多发性内翻性乳头瘤。
这是首次发现犬皮肤乳头瘤的发生与手术有关。手术与乳头瘤发生之间关联的性质尚不确定。然而，表皮浅层受损可能促进乳头瘤的形成。这是在新西兰首次鉴定出CfPV-2。
