Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
Mol Cancer. 2010 Jun 1;9:134. doi: 10.1186/1476-4598-9-134.
MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle regulation, apoptosis, and transformation. Considerable progress has been made in the past few years in understanding the transcription, biogenesis and functional regulation of miRNAs. Numerous studies have implicated altered expression of miRNAs in human cancers, suggesting that aberrant expression of miRNAs is one of the hallmarks for carcinogenesis. In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs.
微小 RNA（miRNAs）是一类小的非编码 RNA，通过精细调节与干细胞发育、细胞分化、细胞周期调控、细胞凋亡和转化等重要信号有关的信号，在细胞或组织的广泛正常和病理过程中发挥关键作用。在过去的几年中，人们在理解 miRNA 的转录、生物发生和功能调节方面取得了相当大的进展。大量研究表明，miRNAs 的表达改变与人类癌症有关，提示异常表达的 miRNAs 是癌症发生的标志之一。在这篇综述中，我们简要讨论了在 miRNA 的微处理器介导生物发生水平上 miRNA 调控的最新发现。
