复制蛋白 A：在复制和修复的交叉路口指挥交通。
Replication protein A: directing traffic at the intersection of replication and repair.
机构信息
College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA.
出版信息
Front Biosci (Landmark Ed). 2010 Jun 1;15(3):883-900. doi: 10.2741/3652.
Abstract
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.
摘要
自最初发现复制蛋白 A (RPA) 作为一种 DNA 复制因子以来，在阐明 RPA 在其他 DNA 代谢途径中的关键作用方面已经取得了很大进展。已经表明 RPA 对于 DNA 复制、DNA 修复、DNA 重组以及在检查点激活中发挥作用的 DNA 损伤反应途径是必需的。这篇综述总结了目前对 RPA 结构、磷酸化和蛋白质-蛋白质相互作用在介导这些 DNA 代谢过程中的理解。
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1
SSB protein diffusion on single-stranded DNA stimulates RecA filament formation.
Nature. 2009 Oct 22;461(7267):1092-7. doi: 10.1038/nature08442. Epub 2009 Oct 11.
2
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
Cell. 2009 Oct 2;139(1):100-11. doi: 10.1016/j.cell.2009.07.043.
3
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Cell. 2009 Oct 2;139(1):87-99. doi: 10.1016/j.cell.2009.07.033.
4
The annealing helicase HARP protects stalled replication forks.
Genes Dev. 2009 Oct 15;23(20):2394-9. doi: 10.1101/gad.1836409. Epub 2009 Sep 30.
5
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA.
Genes Dev. 2009 Oct 15;23(20):2400-4. doi: 10.1101/gad.1831509. Epub 2009 Sep 30.
6
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.
Genes Dev. 2009 Oct 15;23(20):2415-25. doi: 10.1101/gad.1832309. Epub 2009 Sep 30.
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The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.
Genes Dev. 2009 Oct 15;23(20):2405-14. doi: 10.1101/gad.1839909. Epub 2009 Sep 30.
8
Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines.
Head Neck. 2010 May;32(5):636-45. doi: 10.1002/hed.21234.
9
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis.
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10
Prediction of and experimental support for the three-dimensional structure of replication protein A.
Biochemistry. 2009 Aug 25;48(33):7892-905. doi: 10.1021/bi801896s.
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