College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA.
Front Biosci (Landmark Ed). 2010 Jun 1;15(3):883-900. doi: 10.2741/3652.
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.
自最初发现复制蛋白 A (RPA) 作为一种 DNA 复制因子以来，在阐明 RPA 在其他 DNA 代谢途径中的关键作用方面已经取得了很大进展。已经表明 RPA 对于 DNA 复制、DNA 修复、DNA 重组以及在检查点激活中发挥作用的 DNA 损伤反应途径是必需的。这篇综述总结了目前对 RPA 结构、磷酸化和蛋白质-蛋白质相互作用在介导这些 DNA 代谢过程中的理解。
