Wu Miaozong, Wang Bin, Fei Jia, Santanam Nalini, Blough Eric R
Cell Differentiation and Development Center, Marshall University, Huntington, WV 25755 25755-1090, USA.
Front Biosci (Schol Ed). 2010 Jun 1;2(3):1169-88. doi: 10.2741/s125.
The increased costs associated with an ever-growing aged population are expected to pose a significant burden on health care resources. From a biological standpoint, aging is an accelerated deteriorative process in tissue structure and function that is associated with higher morbidity and mortality. The Akt / protein kinase B (PKB) is a family of serine / threonine protein kinases, which play prominent roles in a diverse number of processes including cell survival, cell growth, gene expression, apoptosis, protein synthesis, energy metabolism and oncogenesis. It is likely that age-related changes in tissue structure and function are related to alterations in Akt expression and Akt-dependent signaling. Here we review the role that Akt may play in the aging process and attempt, where possible, to highlight how these data may lead to new directions of inquiry and clinical relevance to the aged.
与不断增长的老年人口相关的成本增加预计将给医疗保健资源带来巨大负担。从生物学角度来看，衰老是组织结构和功能加速恶化的过程，与更高的发病率和死亡率相关。Akt/蛋白激酶B（PKB）是丝氨酸/苏氨酸蛋白激酶家族，在包括细胞存活、细胞生长、基因表达、细胞凋亡、蛋白质合成、能量代谢和肿瘤发生等多种过程中发挥着重要作用。组织结构和功能的年龄相关变化可能与Akt表达和Akt依赖性信号传导的改变有关。在此，我们综述Akt在衰老过程中可能发挥的作用，并尽可能强调这些数据如何可能引领新的研究方向以及与老年人的临床相关性。
