Suda K, Mogaki M
Department of Pathology, Yamanashi Medical University.
Rinsho Byori. 1991 Apr;39(4):416-20.
Branches of the pancreatic duct in obstructive pancreatic disorders were studied histopathologically. Obstructive pancreatic disorders were observed in 25 out of 32 patients with pancreatic carcinoma. The main pancreatic duct was dilated in all 25 cases. Luminal conditions in the branches of the pancreatic duct were divided as follows: dilated, obstructed and unchanged. The dilated duct was found in all 25 cases and showed mainly cystic dilatation with flat epithelia. The obstructed duct was found in 10 cases and revealed granulation tissue in the lumen, disappearance of epithelia and increase in the number of elastic fibers in the periductal space. The pancreatic tissue distal to the tumor frequently showed isolated islets of Langerhans with elastosis. Morphogenesis of elastosis was interpreted as follows: during the process of shortening or disappearance of the duct, elastic fibers increased in number and remained in the fibrous tissue. Hence, the elastosis was considered to be a remnant in which the pancreatic duct had once existed. Therefore, the branches of the pancreatic duct in obstructive pancreatic disorder were classified into four types as follows: dilated, obstructed, remnant and unchanged.
对梗阻性胰腺疾病中胰管分支进行了组织病理学研究。在32例胰腺癌患者中，观察到25例存在梗阻性胰腺疾病。所有25例患者的主胰管均扩张。胰管分支的管腔情况分为以下几种：扩张、梗阻和未改变。在所有25例中均发现扩张的导管，主要表现为伴有扁平上皮的囊性扩张。10例发现梗阻性导管，管腔内可见肉芽组织，上皮消失，导管周围间隙弹性纤维数量增加。肿瘤远端的胰腺组织常显示孤立的胰岛伴有弹性组织变性。弹性组织变性的形态发生如下解释：在导管缩短或消失的过程中，弹性纤维数量增加并留存于纤维组织中。因此，弹性组织变性被认为是胰管曾经存在的残余物。因此，梗阻性胰腺疾病中胰管分支分为以下四种类型：扩张型、梗阻型、残余型和未改变型。
