Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Vet Pathol. 2011 May;48(3):742-50. doi: 10.1177/0300985810369900. Epub 2010 Jun 1.
A progressive debilitating disease of the orbit and adjacent connective tissues of cats has historically been called feline orbital pseudotumor. The authors reviewed clinical, histopathologic, and diagnostic imaging features of this disease in 12 cases from the Comparative Ocular Pathology Laboratory of Wisconsin. The cats' ages ranged from 7 to 16 years (mean, 10.8 years). All cats had a history of severely restricted mobility of the globe and eyelids with secondary corneal disease. Eleven cats (92%) had concurrent involvement of the contralateral eye and/or the oral cavity. Diffuse scleral or episcleral thickening was seen with computed tomography in all clinically affected eyes. Histologically, an insidious infiltration of neoplastic spindle cells in the orbit, eyelids, and periorbital skin and soft tissues, with collagen deposition and a few perivascular lymphocytes, led to entrapment and restricted mobility of the eyelids and orbital tissues. The tumor failed to form a discrete mass, and it spread along fascial planes to the contralateral orbit and eyelids and/or the lips and oral cavity. In all tested cases (n = 10), neoplastic cells were immunohistochemically positive for vimentin, S100 protein, and smooth muscle actin. The authors adopted the term feline restrictive orbital myofibroblastic sarcoma to reflect the restricted mobility of the eyelids and globe and the imaging and histologic features of an invasive yet low-grade myofibroblastic sarcoma.
一种渐进性的猫眶和邻近结缔组织疾病，历史上被称为猫眼眶假瘤。作者回顾了威斯康星州比较眼病理学实验室的 12 例该疾病的临床、组织病理学和诊断成像特征。这些猫的年龄从 7 岁到 16 岁不等（平均年龄为 10.8 岁）。所有猫都有眼球和眼睑严重运动受限以及继发角膜疾病的病史。11 只猫（92%）的对侧眼和/或口腔同时受累。所有临床受影响的眼睛在计算机断层扫描中均可见弥漫性巩膜或球结膜增厚。组织学上，眼眶、眼睑和眼眶皮肤和软组织中隐匿性浸润性肿瘤性梭形细胞，伴有胶原沉积和少量血管周围淋巴细胞，导致眼睑和眼眶组织的束缚和运动受限。肿瘤未能形成离散的肿块，而是沿着筋膜平面扩散到对侧眼眶、眼睑和/或嘴唇和口腔。在所有测试的病例（n=10）中，肿瘤细胞免疫组化阳性表达波形蛋白、S100 蛋白和平滑肌肌动蛋白。作者采用了猫限制性眼眶肌纤维母细胞瘤肉瘤的术语，以反映眼睑和眼球的运动受限以及侵袭性但低度恶性的肌纤维母细胞瘤肉瘤的成像和组织学特征。
