Centre des Sciences du Goût et de l'Alimentation, UMR6265 Centre National de Recherche Scientifique, UMR1324 Institut National de Recherche Agronomique, Université de Bourgogne, Agrosup Dijon, F-21000 Dijon, France.
Genetics. 2010 Aug;185(4):1297-309. doi: 10.1534/genetics.110.117226. Epub 2010 Jun 1.
Sensory communication depends on the precise matching between the emission and the perception of sex- and species-specific signals; understanding both the coevolutionary process and the genes involved in both production and detection is a major challenge. desat1 determines both aspects of communication-a mutation in desat1 simultaneously alters both sex pheromone emission and perception in Drosophila melanogaster flies. We investigated whether the alteration of pheromonal perception is a consequence of the altered production of pheromones or if the two phenotypes are independently controlled by the same locus. Using several genetic tools, we were able to separately manipulate the two pheromonal phenotypes, implying that desat1 is the sole gene responsible, exerting a pleiotropic effect on both transmission and detection. The levels of the five desat1 trancripts, measured in the head and body of manipulated flies, were related to variation in pheromone production. This suggests that the pleiotropic action of desat1 on pheromonal communication depends on the fine regulation of its transcriptional activity.
感官通讯取决于性别和物种特异性信号的发射和感知之间的精确匹配；了解生产和检测过程中的共同进化过程和相关基因是一个主要挑战。desat1 决定了通讯的两个方面——desat1 的突变同时改变了黑腹果蝇的性信息素的排放和感知。我们研究了感知信息素的改变是否是信息素产生改变的结果，或者这两种表型是否由同一基因座独立控制。我们使用几种遗传工具，能够分别操纵这两种信息素表型，这表明 desat1 是唯一负责的基因，对传递和检测都产生多效性影响。在经过操作的果蝇头部和身体中测量的五个 desat1 转录本的水平与信息素产生的变化有关。这表明 desat1 对信息素通讯的多效作用取决于其转录活性的精细调节。
