Kuiken Carla
HIV database project, Los Alamos National Laboratory, Los Alamos, NM, USA.
Antivir Ther. 2010;15(3 Pt B):517-20. doi: 10.3851/IMP1554.
Plans are outlined for a new database for hepatitis antiviral drug resistance mutations that will be closely linked to existing sequence databases. The new database will contain an infrastructure to store all available information on drug resistance mutations for the virus and a mutation can be searched by itself or in conjunction with the sequence information. Self-maintaining and self-updating sequence databases already exist for several viruses. The resistance mutation database would be annotated by authorized users, recruited from among clinicians and researchers familiar with each virus. The new database would provide a central location to find known drug resistance mutations for HBV and HCV; the ability to search the sequence database for each (combination of) mutations, retrieve alignments of relevant sections, and analyse mutation context and other background information; and rapid inclusion of newly found mutations without the need to wait for a publication.
已概述了关于建立一个新的抗肝炎病毒药物耐药性突变数据库的计划，该数据库将与现有的序列数据库紧密相连。新数据库将具备存储该病毒所有可用耐药性突变信息的基础设施，可单独搜索某个突变，也可结合序列信息进行搜索。目前已经存在针对几种病毒的自动维护和自动更新的序列数据库。耐药性突变数据库将由授权用户进行注释，这些用户从熟悉每种病毒的临床医生和研究人员中招募。新数据库将提供一个集中的地点，用于查找乙肝病毒和丙肝病毒已知的耐药性突变；能够在序列数据库中搜索每个（组合的）突变，检索相关部分的比对结果，并分析突变背景及其他背景信息；还能够快速纳入新发现的突变，而无需等待发表。
