乙型和丙型肝炎病毒的病毒学及抗病毒靶点
Virology of hepatitis B and C viruses and antiviral targets.
作者信息
Pawlotsky Jean-Michel
机构信息
Department of Virology, INSERM U635, Hôpital Henri Mondor, Université Paris 12, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.
出版信息
J Hepatol. 2006;44(1 Suppl):S10-3. doi: 10.1016/j.jhep.2005.11.005. Epub 2005 Nov 21.
Hepatitis B and C viruses belong to two distinct virus families, the Hepadnaviridae and the Flaviviridae, respectively, and have different virological characteristics. Better knowledge of their lifecycles and variability offers the opportunity to develop novel therapeutic approaches and classes of drugs. The issue of cccDNA clearance, however, remains in hepatitis B treatment, whereas HCV infection is curable.
乙型肝炎病毒和丙型肝炎病毒分别属于两个不同的病毒科，即嗜肝DNA病毒科和黄病毒科，并且具有不同的病毒学特征。对它们生命周期和变异性的深入了解为开发新的治疗方法和药物类别提供了机会。然而，在乙型肝炎治疗中，共价闭合环状DNA（cccDNA）清除的问题仍然存在，而丙型肝炎感染是可治愈的。
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