Department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
Horm Res Paediatr. 2010;74(3):165-71. doi: 10.1159/000281018. Epub 2010 May 28.
Data concerning final height are completely lacking in human immunodeficiency virus (HIV)-infected children.
Retrospective evaluation of auxological data up to final height in a cohort of patients with perinatal HIV infection.
In 95 Caucasian patients (57 females and 38 males, median age 17.5 years) the following data were evaluated as standard deviation (SD) score: prepubertal height (PrH), height velocity (HV), final height (FH), target height (TH), FH minus PrH, predicted adult height (PAH), FH minus PAH, and FH minus TH.
Patients showed a significantly reduced PrH and FH compared to their TH (p < 0.001), even if no difference was evidenced between PrH and FH. Age at puberty onset displayed a negative significant correlation with PrH (p = 0.002) and CD4+ cell percentage (p < 0.01). Finally, HV displayed a significant correlation with viremia (p = 0.001), but not with CD4+ cell percentage.
HIV perinatally infected patients show a FH significantly reduced and not in accordance with TH. Our data seem to suggest that the losses in stature accumulated throughout the total period of childhood and adolescence may contribute to their reduced FH.
关于人类免疫缺陷病毒（HIV）感染儿童最终身高的数据完全缺失。
对围产期 HIV 感染患者队列的生长学数据进行回顾性评估，直至最终身高。
在 95 例白种人患者（57 名女性和 38 名男性，中位年龄 17.5 岁）中，评估了以下数据的标准差（SD）评分：青春前期身高（PrH）、身高生长速度（HV）、最终身高（FH）、靶身高（TH）、FH 与 PrH 之差、预测成人身高（PAH）、FH 与 PAH 之差以及 FH 与 TH 之差。
与 TH 相比，患者的 PrH 和 FH 明显降低（p < 0.001），尽管 PrH 和 FH 之间没有差异。青春期开始年龄与 PrH（p = 0.002）和 CD4+细胞百分比（p < 0.01）呈负显著相关。最后，HV 与病毒载量呈显著正相关（p = 0.001），但与 CD4+细胞百分比无关。
围产期感染 HIV 的患者 FH 明显降低，与 TH 不符。我们的数据似乎表明，整个儿童期和青春期积累的身高损失可能导致他们 FH 降低。
