Seoul, Korea From the Gyalumhan Plastic Aesthetic Clinic.
Plast Reconstr Surg. 2010 Jun;125(6):1693-1705. doi: 10.1097/PRS.0b013e3181d0ad03.
The authors investigated retrospectively the long-term treatment effects of botulinum toxin by analyzing the follow-up data of masseter hypertrophy patients at the Gyalumhan Plastic Aesthetic Clinic, located in Seoul, Korea, from March of 2001 to September of 2007. This is a second follow-up study following the previous study report in 2005.
A total of 121 patients treated for more than 1 year with injection of botulinum toxin type A were included in this analysis. At every patient's visit, masseter muscle thickness was measured using ultrasonography. The dose of injection was 100 to 140 U of Dysport for each side based on the muscle thickness.
Of a total 121 patients, six patients received two injections, 28 patients received three injections, 41 patients received four injections, 23 patients received five injections, 16 patients received six injections, six patients received seven injections, and one patient received eight injections. Overall masseter muscle size was reduced from 13.32 mm at the baseline visit to 9.94 mm at the last visit on average. As the number of visits increased through two to eight visits, the mean muscle size was decreased. According to the increase in the number of visits, the mean dose was decreased. There was no significant difference in muscle reduction effect analyzed by age subgroup. The muscle reduction effect after botulinum toxin treatment was better in patients with thicker masseter muscles.
Botulinum toxin type A injections have a long-term effect on masseter muscle hypertrophy. A positive correlation was found between the number of injections and the decrease of muscle volume.
作者通过分析韩国首尔嘉恋整形美容诊所 2001 年 3 月至 2007 年 9 月间接受肉毒毒素治疗的咬肌肥大患者的随访资料，回顾性研究肉毒毒素的长期治疗效果。这是继 2005 年之前的研究报告之后的第二次随访研究。
本分析共纳入 121 例接受 A 型肉毒毒素注射治疗 1 年以上的患者。每次就诊时，均采用超声测量咬肌厚度。根据肌肉厚度，每侧注射剂量为 100 至 140U 的 Dysport。
121 例患者中，6 例接受 2 次注射，28 例接受 3 次注射，41 例接受 4 次注射，23 例接受 5 次注射，16 例接受 6 次注射，6 例接受 7 次注射，1 例接受 8 次注射。总体而言，咬肌大小从基线就诊时的 13.32mm 平均减少到末次就诊时的 9.94mm。随着就诊次数从 2 次增加到 8 次，平均肌肉大小逐渐减小。随着就诊次数的增加，平均剂量逐渐减少。按年龄亚组分析，肌肉减少效果无显著差异。肉毒毒素治疗后，咬肌较厚的患者肌肉减少效果更好。
A 型肉毒毒素注射对咬肌肥大具有长期疗效。注射次数与肌肉体积减少呈正相关。
