State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China.
Int J Nanomedicine. 2010 May 13;5:331-5. doi: 10.2147/ijn.s9869.
The aim of the study was to investigate a porous nanohydroxyapatite/polyamide 66 (n-HA/PA66) scaffold material that was implanted into muscle and tibiae of 16 New Zealand white rabbits to evaluate the biocompatibility and osteogenesis and osteoinductivity of the materials in vivo. The samples were harvested at 2, 4, 12 and 26 weeks respectively, and subjected to histological analysis. At 2 weeks, the experiment showed that osteogenesis was detected in porous n-HA/PA66 composite and the density of new bone formation was similar to the surrounding host bone at 12 weeks. The study indicated that three-dimensional pore structures could facilitate cell adhesion, differentiation and proliferation, and help with fibrovascular and nerve colonization. In conclusion, porous n-HA/PA66 scaffold material could be a good candidate as a bone substitute material used in clinics due to its excellent histocompatibility, osteoconductivity and osteoinductivity.
本研究旨在探究一种多孔纳米羟基磷灰石/聚酰胺 66（n-HA/PA66）支架材料，将其植入 16 只新西兰白兔的肌肉和胫骨中，以评估材料在体内的生物相容性和成骨及成骨诱导活性。分别在 2、4、12 和 26 周时取出样本进行组织学分析。在 2 周时，实验表明多孔 n-HA/PA66 复合材料中检测到成骨，且 12 周时新骨形成的密度与周围宿主骨相似。研究表明，三维孔隙结构有助于细胞黏附、分化和增殖，并有助于纤维血管和神经定植。总之，多孔 n-HA/PA66 支架材料由于其良好的组织相容性、骨传导性和成骨诱导性，有望成为一种良好的临床用骨替代材料。
