Ungersböck A, Pohler O, Perren S M
AO/ASIF Research Institute Davos, Switzerland.
Biomed Mater Eng. 1994;4(4):317-25.
Recently, a dominant influence of the surface roughness parameters for the soft tissue reaction at the implant tissue interface was found in an experimental study on sheep. The purpose of the present study is to correlate the surface roughness parameters of different experimental bone plates to the results of the histomorphometric analyses of the adjacent soft tissues. Pure titanium plates (35 x 5 x 1 mm) with six different surface treatments and electropolished stainless steel plates were tested. Prior to implantation the surface roughness parameters were determined using a profilometer and a scanning electron microscope. The tibia of adult rabbits served as test sites. At least four plates of each type were implanted. Three months postoperatively the implants were harvested with an intact tissue envelope and were left in situ for the histological preparation. The difference in the roughness parameters is statistically significant for most surface conditions and has an effect on the soft tissue reaction. The histological evaluation shows a significant higher number of blood vessels for steel plates in comparison to titanium plates with handground and blasted surface conditions. For the rough type of anodized titanium surfaces a significantly thinner soft tissue capsule is found, compared to electropolished steel plates. For the steel plates a fluid film was found between the implant and the adjacent tissue layer. The material and the surface roughness of the implant, determine the tissue reaction at the interface. The rough type of anodized titanium implants seems to be preferable.
最近，在一项对绵羊的实验研究中发现，植入物-组织界面处的软组织反应受表面粗糙度参数的影响很大。本研究的目的是将不同实验性骨板的表面粗糙度参数与相邻软组织的组织形态计量学分析结果相关联。测试了具有六种不同表面处理的纯钛板（35×5×1毫米）和电解抛光不锈钢板。植入前，使用轮廓仪和扫描电子显微镜测定表面粗糙度参数。成年兔的胫骨作为测试部位。每种类型至少植入四块板。术后三个月，将植入物连同完整的组织包膜一起取出，并留在原位进行组织学制备。在大多数表面条件下，粗糙度参数的差异具有统计学意义，并对软组织反应有影响。组织学评估显示，与具有手工研磨和喷砂表面条件的钛板相比，钢板的血管数量明显更多。与电解抛光钢板相比，对于粗糙型阳极氧化钛表面，发现软组织包膜明显更薄。对于钢板，在植入物和相邻组织层之间发现了一层液膜。植入物的材料和表面粗糙度决定了界面处的组织反应。粗糙型阳极氧化钛植入物似乎更可取。
