• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

采用固相萃取结合薄层色谱和气相色谱/质谱联用法对尿液进行全面药物筛查。

Comprehensive drug screening in urine using solid-phase extraction and combined TLC and GC/MS identification.

作者信息

Lillsunde P, Korte T

机构信息

National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

出版信息

J Anal Toxicol. 1991 Mar-Apr;15(2):71-81. doi: 10.1093/jat/15.2.71.

DOI:10.1093/jat/15.2.71
PMID:2051748
Abstract

A simple and sensitive identification system for the detection of a broad spectrum of drugs is described. ChemElut extraction tubes were used for isolation of drugs from urine. Specimens were screened by thin-layer chromatography (TLC) and confirmed by gas chromatography/mass spectrometry (GC/MS). Special procedures for buprenorphine, cannabinoids, cocaine, LSD, morphine, phencyclidine, halogenated hydrocarbons, paracetamol, and alcohols were used. This system is useful for screening samples in misuse, impaired driving, poisoning, and other forensic cases. It covers about 300 substances including all potentially abused drugs and their metabolites.

摘要

本文描述了一种用于检测多种药物的简单且灵敏的识别系统。使用ChemElut萃取管从尿液中分离药物。样本先用薄层色谱法(TLC)进行筛查,然后用气相色谱/质谱联用仪(GC/MS)进行确证。对丁丙诺啡、大麻素、可卡因、麦角酸二乙酰胺(LSD)、吗啡、苯环己哌啶、卤代烃、对乙酰氨基酚和酒精采用了特殊程序。该系统可用于滥用药物、酒驾、中毒及其他法医案件中的样本筛查。它涵盖了约300种物质,包括所有潜在的滥用药物及其代谢物。

相似文献

1
Comprehensive drug screening in urine using solid-phase extraction and combined TLC and GC/MS identification.采用固相萃取结合薄层色谱和气相色谱/质谱联用法对尿液进行全面药物筛查。
J Anal Toxicol. 1991 Mar-Apr;15(2):71-81. doi: 10.1093/jat/15.2.71.
2
Rapid, simple, and highly sensitive analysis of drugs in biological samples using thin-layer chromatography coupled with matrix-assisted laser desorption/ionization mass spectrometry.采用薄层色谱-基质辅助激光解吸电离质谱联用技术,对生物样品中的药物进行快速、简单、高灵敏度的分析。
Anal Bioanal Chem. 2012 Jan;402(3):1257-67. doi: 10.1007/s00216-011-5576-0. Epub 2011 Dec 7.
3
Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.液相色谱-高分辨率质谱(LC-HR/MS)在临床毒理学中的作用。
Clin Toxicol (Phila). 2012 Sep;50(8):733-42. doi: 10.3109/15563650.2012.713108. Epub 2012 Aug 13.
4
Rapid solid-phase extraction/derivatization system for sample preparation and gas chromatographic/mass spectrometric determination of drugs in human urine.用于人尿中药物样品制备及气相色谱/质谱测定的快速固相萃取/衍生化系统
Rapid Commun Mass Spectrom. 1997;11(3):298-306. doi: 10.1002/(SICI)1097-0231(19970215)11:3<298::AID-RCM775>3.0.CO;2-#.
5
Comparison of new solid-phase extraction methods for chromatographic identification of drugs in clinical toxicological analysis.临床毒理学分析中用于药物色谱鉴定的新型固相萃取方法比较
Clin Biochem. 1996 Dec;29(6):529-40. doi: 10.1016/s0009-9120(96)00096-3.
6
General unknown screening in hair by liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS).采用液相色谱-四极杆飞行时间质谱(LC-QTOF-MS)对头发进行一般未知物筛查。
Forensic Sci Int. 2012 May 10;218(1-3):68-81. doi: 10.1016/j.forsciint.2011.10.004. Epub 2011 Oct 27.
7
[Optimization of the solid-phase extraction procedure for the screening of the medicinal and narcotic substances in the blood by gas chromatography with mass-spectrometric detection].[通过气相色谱-质谱检测法优化用于筛查血液中药物和麻醉物质的固相萃取程序]
Sud Med Ekspert. 2017;60(1):29-35. doi: 10.17116/sudmed201760129-35.
8
Confirmatory tests for drugs in the workplace by gas chromatography-mass spectrometry.采用气相色谱-质谱联用技术对工作场所中的药物进行确证检测。
J Chromatogr A. 1994 Jul 15;674(1-2):73-86. doi: 10.1016/0021-9673(94)85218-9.
9
Urine Multi-drug Screening with GC-MS or LC-MS-MS Using SALLE-hybrid PPT/SPE.采用SALLE混合PPT/SPE技术通过气相色谱-质谱联用仪(GC-MS)或液相色谱-串联质谱仪(LC-MS-MS)进行尿液多药物筛查。
J Anal Toxicol. 2018 Nov 1;42(9):617-624. doi: 10.1093/jat/bky032.
10
Salting out improves solid-phase extraction recoveries on Abselut-Tox columns for broad spectrum drug screening.盐析可提高Abselut-Tox柱上用于广谱药物筛选的固相萃取回收率。
J Anal Toxicol. 2002 Jan-Feb;26(1):48-51. doi: 10.1093/jat/26.1.48.

引用本文的文献

1
Detection of Cannabinoids in Oral Fluid Specimens as the Preferred Biological Matrix for a Point-of-Care Biosensor Diagnostic Device.在口腔液样本中检测大麻素作为即时检测生物传感器诊断设备的首选生物基质。
Biosensors (Basel). 2024 Feb 27;14(3):126. doi: 10.3390/bios14030126.
2
Urine Toxicology in Adults Evaluated for a Central Hypersomnia and How the Results Modify the Physician's Diagnosis.针对中枢性睡眠过度进行评估的成年患者的尿液毒理学检查以及检查结果如何影响医生的诊断
J Clin Sleep Med. 2016 Nov 15;12(11):1499-1505. doi: 10.5664/jcsm.6276.
3
Comparison of liquid-liquid extraction-thin layer chromatography with solid-phase extraction-high-performance thin layer chromatography in detection of urinary morphine.
液-液萃取-薄层色谱法与固相萃取-高效薄层色谱法在尿吗啡检测中的比较
J Biomed Res. 2011 Sep;25(5):362-7. doi: 10.1016/S1674-8301(11)60048-1.
4
Analysis of "Ecstasy" by capillary electrophoresis.采用毛细管电泳法分析“摇头丸”。
Int J Legal Med. 1996;109(2):53-7. doi: 10.1007/BF01355516.