Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Division of Child Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
Cephalalgia. 2022 Jul;42(8):793-797. doi: 10.1177/03331024221076483. Epub 2022 Mar 18.
Headaches with marked, specific response to indomethacin occur in children, but the phenotypic spectrum of this phenomenon has not been well-studied.
We reviewed pediatric patients with headache showing ≥80% improvement with indomethacin, from seven academic medical centers.
We included 32 pediatric patients (16 females). Mean headache onset age was 10.9 y (range 2-16 y). Headache syndromes included hemicrania continua (n = 13), paroxysmal hemicrania (n = 10), primary stabbing headache (n = 2), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (n = 1), primary exercise headache (n = 1) and primary cough headache (n = 1). Adverse events were reported in 13, most commonly gastrointestinal symptoms, which often improved with co-administration of gastro-protective agents.
Indomethacin-responsive headaches occur in children and adolescents, and include headache syndromes, such as primary cough headache, previously thought to present only in adulthood. The incidence of adverse events is high, and patients must be co-treated with a gastroprotective agent.
在儿童中，出现明显、特定对吲哚美辛有反应的头痛，但这种现象的表型谱尚未得到很好的研究。
我们回顾了来自七个学术医疗中心的对吲哚美辛有≥80%改善的头痛的儿科患者。
我们纳入了 32 名儿科患者（女性 16 名）。头痛发病年龄平均为 10.9 岁（范围 2-16 岁）。头痛综合征包括慢性偏头痛（n=13）、阵发性偏头痛（n=10）、原发性刺痛性头痛（n=2）、伴有结膜充血和流泪的短暂单侧神经痛样头痛发作（n=1）、原发性运动性头痛（n=1）和原发性咳嗽性头痛（n=1）。13 名患者报告出现不良事件，最常见的是胃肠道症状，常因同时给予胃保护剂而改善。
吲哚美辛反应性头痛发生于儿童和青少年，包括既往认为仅在成年期出现的头痛综合征，如原发性咳嗽性头痛。不良事件的发生率较高，患者必须同时接受胃保护剂治疗。
