血红素加氧酶-1 系统与胃肠道肿瘤。
Heme oxygenase-1 system and gastrointestinal tumors.
机构信息
Institute of Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, Guangdong Province, China.
出版信息
World J Gastroenterol. 2010 Jun 7;16(21):2633-7. doi: 10.3748/wjg.v16.i21.2633.
Abstract
Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in many physiological and pathophysiological processes. A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors. The interest in this system by investigators involved in gastrointestinal tumors is fairly recent, and few papers on HO-1 have touched upon this subject. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to date. The implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed.
摘要
血红素加氧酶-1（HO-1）系统将血红素分解为三种产物：一氧化碳、胆红素/胆红素和游离铁。它参与许多生理和病理生理过程。大量数据表明 HO-1 在肿瘤的形成、生长和转移中起作用。研究胃肠道肿瘤的研究人员对该系统的兴趣是最近才有的，而且很少有关于 HO-1 的论文涉及到这个主题。本综述重点介绍了 HO-1 诱导的生理意义及其在迄今为止研究的胃肠道肿瘤中的可能作用的最新认识。还讨论了 HO-1 在胃肠道肿瘤中可能的治疗干预的意义。
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