Cancer Institute, Affiliated Tumor Hospital, Guangzhou Medical University, Guangzhou 510095, Guangdong Province, China.
World J Gastroenterol. 2011 Oct 14;17(38):4283-8. doi: 10.3748/wjg.v17.i38.4283.
Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future.
血红素加氧酶-1（HO-1）系统催化血红素生成生物活性产物：一氧化碳、胆红素/胆红素和游离铁。它参与维持细胞内环境平衡和许多生理及病理生理过程。越来越多的证据表明，HO-1 的激活可能在胃肠道的急性和慢性炎症中发挥重要的保护作用。本综述重点介绍了 HO-1 诱导的生理意义及其在迄今为止研究的胃肠道炎症中的可能作用的最新认识。通过药理学手段或基因治疗上调 HO-1 的能力可能为未来的胃肠道炎症提供治疗策略。
