Ceresini Graziano, Morganti Simonetta, Maggio Marcello, Usberti Elisa, Fiorino Ilaria, Artoni Andrea, Teresi Giulio, Belli Serena, Ridolfi Valentina, Valenti Giorgio, Ceda Gian Paolo
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics Endocrine Unit, University of Parma, Parma, Italy.
Acta Biomed. 2010;81 Suppl 1:31-6.
Subclinical thyroid disease (STD) is defined as circulating concentrations of free T4 and free T3 within their respective reference ranges in the presence of abnormal circulating concentrations of TSH. SCD is being diagnosed more frequently in clinical practice and is reported to be more prevalent in elderly as compared to young or adult subjects. The clinical impact of subclinical thyroid dysfunction is still a matter of debate, although it has been associated with various negative clinical outcomes, such as increased cardiovascular risk, reduction in bone density, decline in cognitive function, and increased risk of overt thyroid dysfunction. The treatment of STD is controversial and there is no consensus on the TSH cutoff values which can be used as indicators for treatment, especially in elderly subjects. In the present review, we report data on the prevalence of STD and on the potential clinical consequences of these disorders. Also, data of the Literature regarding the issue of the treatment of STD in relation to the age of the patient are reported.
亚临床甲状腺疾病（STD）的定义为：在促甲状腺激素（TSH）循环浓度异常的情况下，游离甲状腺素（T4）和游离三碘甲状腺原氨酸（T3）的循环浓度处于各自的参考范围内。在临床实践中，亚临床甲状腺疾病的诊断越来越频繁，据报道，与年轻或成年受试者相比，老年人中该病更为普遍。尽管亚临床甲状腺功能障碍与各种负面临床结果相关，如心血管风险增加、骨密度降低、认知功能下降以及显性甲状腺功能障碍风险增加，但亚临床甲状腺功能障碍的临床影响仍存在争议。亚临床甲状腺疾病的治疗存在争议，对于可作为治疗指标的TSH临界值尚无共识，尤其是在老年受试者中。在本综述中，我们报告了亚临床甲状腺疾病的患病率数据以及这些疾病潜在的临床后果。此外，还报告了文献中有关根据患者年龄治疗亚临床甲状腺疾病问题的数据。
