Anar Ceyda, Bicmen Can, Yapicioglu Sena, Unsal Ipek, Halilcolar Huseyin, Yilmaz Ufuk
Dr. Suat Seren Training and Research, Hospital for Chest Diseases and Surgery, Department of Chest Diseases, Izmir Turkey.
New Microbiol. 2010 Apr;33(2):117-27.
The present study investigated the antibody response against influenza vaccine and also the efficacy of vaccination on clinical findings in patients with Chronic Obstructive Pulmonary Disease (COPD) following influenza vaccination. A total of 82 cases with COPD (44 cases as vaccinated and 38 cases as unvaccinated) were evaluated clinically and 21 healthy volunteers were also included in the study as a control group. Influenza (A and B) Ig M and Ig G parameters were analyzed quantitatively in blood samples of the vaccinated group and healthy volunteers by ELISA method once before vaccination and one month and one year after vaccination. The presence of dyspnoea, increased sputum production and/or purulence were accepted as criteria of acute exacerbation. The number of hospital presentations was significantly lower in the vaccinated group and higher in severe cases with COPD in unvaccinated group. Vaccinated cases in the study group experienced significantly fewer episodes of pneumonia, hospitalization and intensive care. Quantitative influenza (A and B) antibody IgG levels significantly increased in these patients as well. In conclusion, seasonal influenza vaccination with the trivalent influenza split virion vaccine especially in severe or very severe COPD patients who need hospitalization was evaluated as beneficial in clinical use.
本研究调查了慢性阻塞性肺疾病（COPD）患者接种流感疫苗后的抗体反应以及疫苗接种对临床症状的疗效。总共82例COPD患者（44例接种疫苗，38例未接种疫苗）接受了临床评估，21名健康志愿者也作为对照组纳入研究。通过ELISA方法，在接种疫苗组和健康志愿者接种疫苗前、接种后1个月和1年后的血液样本中定量分析流感（A和B）IgM和IgG参数。呼吸困难、痰液产生增加和/或脓性痰被视为急性加重的标准。接种疫苗组的住院次数明显低于未接种疫苗组中COPD严重病例。研究组中接种疫苗的病例肺炎、住院和重症监护的发作次数明显减少。这些患者的流感（A和B）抗体IgG定量水平也显著升高。总之，对于尤其是需要住院治疗的重度或极重度COPD患者，使用三价流感裂解病毒疫苗进行季节性流感疫苗接种在临床应用中被评估为有益。
