Di Guardo Giovanni, Marruchella Giuseppe
University of Teramo, Faculty of Veterinary Medicine, Department of Comparative Biomedical Sciences, Teramo, Italy.
New Microbiol. 2010 Apr;33(2):183-4.
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE)--or prion disease (PD)--that has become of increasing concern throughout years among different captive and free-living deer species and populations in North America. Starting from the recent pre-clinical evidence of prion infectivity in faecal material from CWD-infected mule deer (Odocoileus hemionus), this contribution takes into special consideration the potential role of certain gut inflammatory conditions as a factor modulating the infectivity titres and, consequently, also the CWD prion faecal excretion rate.
慢性消耗病（CWD）是一种传染性海绵状脑病（TSE）——即朊病毒病（PD），多年来在北美不同圈养和野生鹿种及种群中受到越来越多的关注。从最近关于慢性消耗病感染的骡鹿（Odocoileus hemionus）粪便中朊病毒传染性的临床前证据出发，本论文特别考虑了某些肠道炎症状况作为调节感染滴度以及慢性消耗病朊病毒粪便排泄率的一个因素的潜在作用。
