Orriols R, Drobnic M E, Sampol G, Ferrer J, Román A, Morell F
Servicio de Neumología, Hospital General Vall d'Hebron, Barcelona.
Med Clin (Barc). 1991 Apr 27;96(16):611-3.
A study of delayed nonspecific cutaneous hypersensitivity in extrinsic allergic alveolitis and in idiopathic pulmonary fibrosis.
13 patients with extrinsic allergic alveolitis, 10 with idiopathic pulmonary fibrosis, 34 with sarcoidosis and a control group of 110 subjects without respiratory disease or apparent defects in cell immunity were evaluated. The skin tests of delayed hypersensitivity were carried out with five antigenic extracts (candidin, staphylococcal toxoid, tuberculin-PPD, trichophyllin, streptokinase-streptodornase). The reactions were read after 48 hours. Delayed nonspecific cutaneous hypersensitivity was globally calculated, both quantitatively (sum of the mean diameters) and quantitatively (overall average of positive reactions).
No significant differences were found between the group of patients with idiopathic pulmonary fibrosis and the control group, nor between those with extrinsic allergic alveolitis and those with sarcoidosis. However, differences were found between the control group and the patients with extrinsic allergic alveolitis, both in the quantitative and the qualitative analysis.
Delayed nonspecific cutaneous hypersensitivity in extrinsic allergic alveolitis is depressed in a similar way as in sarcoidosis, whereas it appears to be preserved in idiopathic pulmonary fibrosis. Therefore, extrinsic allergic alveolitis should be considered as another cause of reduction of delayed nonspecific cutaneous hypersensitivity as it is the case with sarcoidosis.
一项关于外源性过敏性肺泡炎和特发性肺纤维化中迟发性非特异性皮肤超敏反应的研究。
对13例外源性过敏性肺泡炎患者、10例特发性肺纤维化患者、34例结节病患者以及110名无呼吸系统疾病或明显细胞免疫缺陷的对照组受试者进行了评估。采用五种抗原提取物（念珠菌素、葡萄球菌类毒素、结核菌素-PPD、曲菌素、链激酶-链道酶）进行迟发性超敏反应皮肤试验。48小时后读取反应结果。从定量（平均直径总和）和定性（阳性反应总体平均值）两方面对迟发性非特异性皮肤超敏反应进行整体计算。
特发性肺纤维化患者组与对照组之间、外源性过敏性肺泡炎患者与结节病患者之间均未发现显著差异。然而，在定量和定性分析中，对照组与外源性过敏性肺泡炎患者之间均存在差异。
外源性过敏性肺泡炎中的迟发性非特异性皮肤超敏反应与结节病一样以类似方式受到抑制，而在特发性肺纤维化中似乎保持正常。因此，外源性过敏性肺泡炎应被视为迟发性非特异性皮肤超敏反应降低的另一个原因，如同结节病的情况一样。
