Orriols R, Morell F, Curull V, Roman A, Sampol G
Section of Pneumology, Hospital General Vall d'Hebron, Barcelona, Spain.
Thorax. 1989 Feb;44(2):132-5. doi: 10.1136/thx.44.2.132.
The relation between non-specific delayed cutaneous hypersensitivity and bird fancier's lung was investigated in 13 patients with the disorder. They were compared with 50 subjects who had no reason to have decreased non-specific delayed cutaneous hypersensitivity (control group) and 34 patients with pulmonary sarcoidosis. In addition, 13 patients with bird fancier's lung (11 of the original group) were tested at least one year after avoiding exposure to the causal antigen. Five antigens (candidine, staphylococcal toxoid, tuberculin purified protein derivative, trichophyton, and streptokinase-streptodornase) were injected intradermally (0.1 ml) and the mean weal diameter was measured at 48 hours. The mean weal size was significantly less in the subjects with bird fancier's lung at the time of diagnosis than in the control group (2.23 v 5.66 mm) but did not differ significantly from that of the subjects with sarcoidosis (2.80 mm) or from that of the bird fanciers with no exposure to the causal antigen for one year (2.75 mm). The impairment of non-specific delayed cutaneous hypersensitivity in patients with bird fancier's lung appears to be quantitatively similar to that occurring in sarcoidosis.
在13例患有鸟饲者肺的患者中研究了非特异性迟发性皮肤超敏反应与鸟饲者肺之间的关系。将他们与50名无理由出现非特异性迟发性皮肤超敏反应降低的受试者（对照组）以及34例肺结节病患者进行比较。此外，对13例鸟饲者肺患者（原组中的11例）在避免接触致病抗原至少一年后进行了检测。将五种抗原（假丝菌素、葡萄球菌类毒素、结核菌素纯蛋白衍生物、毛癣菌和链激酶-链道酶）皮内注射（0.1毫升），并在48小时时测量平均风团直径。在诊断时，鸟饲者肺患者的平均风团大小明显小于对照组（2.23对5.66毫米），但与结节病患者的平均风团大小（2.80毫米）或与一年未接触致病抗原的鸟饲者的平均风团大小（2.75毫米）无显著差异。鸟饲者肺患者中非特异性迟发性皮肤超敏反应的损害在数量上似乎与结节病中发生的损害相似。
