Yan Bing-yu, Zhang Li, Song Li-zhi
Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, Shandong, China.
Zhongguo Yi Miao He Mian Yi. 2009 Dec;15(6):524-6.
To reveal the hepatitis A vaccine (HepA) coverage among pre-school children in Shandong province before Hepatitis A vaccine was introduced to the EPI and to provide evidence for improving the strategy for hepatitis A control.
A cross-section survey was conducted among children aged between 2 and 6 years old in Shandong province in March 2008. The study population was selected by random sampling method and HepA immunization history was obtained by immunization record or recall.
78.90% had received one dose of HepA at least. The coverage rate decreased with age and the differences in three age groups were statistically significant (chi2 = 11.54, P = 0.02). The coverage rates among the boys and girls were 77.67% and 80.30% respectively, the difference was not significantly (chi2 = 1.17, P = 0.28). The HepA coverage rates among the children living in the eastern areas and in the richer areas were higher than the centrale and western areas and poverty areas, the difference has statistic significance (chi2 = 27.25, 58.17, P < 0.001).
The HepA routine immunization should be enhanced, especially in central and western areas and a HepA catch-up campaign should be conducted among the pre-school children in Shandong province.
了解甲型肝炎疫苗（HepA）纳入山东省扩大免疫规划（EPI）前学龄前儿童的甲型肝炎疫苗接种情况，为完善甲型肝炎防控策略提供依据。
2008年3月对山东省2～6岁儿童进行横断面调查。采用随机抽样方法选取研究对象，通过免疫接种记录或回忆获得甲型肝炎疫苗免疫史。
至少接种1剂甲型肝炎疫苗的儿童占78.90%。接种率随年龄增长而降低，3个年龄组间差异有统计学意义（χ2 = 11.54，P = 0.02）。男、女童接种率分别为77.67%和80.30%，差异无统计学意义（χ2 = 1.17，P = 0.28）。东部地区和经济较发达地区儿童甲型肝炎疫苗接种率高于中部、西部地区和贫困地区，差异有统计学意义（χ2 = 27.25、58.17，P < 0.001）。
应加强山东省甲型肝炎疫苗常规免疫接种工作，尤其在中西部地区，并对学龄前儿童开展甲型肝炎疫苗查漏补种活动。
