Kong Q, Yan B Y, Lyu J J, Feng Y, Liu J Y, Song L Z, Xu Q, Zhang L, Xu A Q
School of Public Health, Shandong University, Jinan 250012, China.
Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Jun 6;51(6):480-483. doi: 10.3760/cma.j.issn.0253-9624.2017.06.005.
To evaluate prevalence of hepatitis A antibody (anti-HAV IgG) among population covered by different hepatitis A vaccine immunization strategies in Shandong Province in 2015. In October 2015, according to the geographical location of Shandong Province, the stratified random sampling method was used to stratify the 17 municipal distrcts, and the random number table method was used for sampling, First, two eastern cites (Qingdao, Rizhao), two western cities (Liaocheng, Zaozhuang) and three central cities (Jinan, Zibo and Laiwu) were selected; secondly, one county was drawn from each city. Finally, the participants were divided into five age groups including ≤7 years (age group covered by free hepatitis A vaccination strategy), 8-11 years (age group who receive hepatitis A vaccination at their own charge), 12-24 years (age group covered by catch-up vaccination of hepatitis A), 25-34 years (age group born before hepatitis A vaccine was used) and ≥35 years (age group born before hepatitis A vaccine was used). After all the paticipants or their guardians asked and registered basic information such as age, gender, home address, blood samples were collected from them and anti-HAV IgG was detected by ELISA method. The positive rate of anti-HAV IgG and 95% were calculated. A total of 1 654 participants were involved in the final analysis, including 856 males (51.75%) and 798 females (48.25%) whose mean age was (13.44±13.06) years. The crude positive rate of anti-HAV IgG was 91.41% (1 512/1 654, 95% 89.96%-92.72%) and the age-adjusted rate was 90.93% (95% 90.92%-90.94%). The positive rates of anti-HAV IgG was at the highest level in the age group of ≤7 years (95.90%, 95% 95.88%-95.91%) and was at the lowest level in the age group of 25-34 years (83.23%, 95% 83.21%-83.25%). The age-specific positive rates of anti-HAV IgG in eastern areas (96.79%, 95% 96.78%-96.80%) were higher than those in both middle areas (86.66%, 95% 86.65%-86.67%) and western areas (91.96%, 95% 91.95%-91.97%). The positive rate of anti-HAV IgG was high among the general population in Shandong Province, but relatively low among young and middle-aged adults. Besides the routine immunization of hepatitis A among the children, more efforts should be taken for the prevention and control of hepatitis A among young and middle-aged adults in Shandong Province, especially in central and western areas.
评估2015年山东省不同甲型肝炎疫苗免疫策略覆盖人群中甲肝抗体（抗-HAV IgG）的流行情况。2015年10月，根据山东省地理位置，采用分层随机抽样方法对17个市辖区进行分层，并用随机数字表法进行抽样。首先，选取两个东部城市（青岛、日照）、两个西部城市（聊城、枣庄）和三个中部城市（济南、淄博和莱芜）；其次，从每个城市抽取一个县。最后，将参与者分为五个年龄组，包括≤7岁（免费甲型肝炎疫苗接种策略覆盖年龄组）、8-11岁（自费接种甲型肝炎疫苗年龄组）、12-24岁（甲型肝炎补种年龄组）、25-34岁（甲型肝炎疫苗使用前出生年龄组）和≥35岁（甲型肝炎疫苗使用前出生年龄组）。在所有参与者或其监护人询问并登记年龄、性别、家庭住址等基本信息后，采集他们的血样，并用ELISA法检测抗-HAV IgG。计算抗-HAV IgG的阳性率及95%可信区间。最终纳入分析的参与者共1654人，其中男性856人（51.75%），女性798人（48.25%），平均年龄为（13.44±13.06）岁。抗-HAV IgG的粗阳性率为91.41%（1512/1654，95%可信区间89.96%-92.72%），年龄调整率为90.93%（95%可信区间90.92%-90.94%）。抗-HAV IgG阳性率在≤7岁年龄组最高（95.90%，95%可信区间95.88%-95.91%），在25-34岁年龄组最低（83.23%，95%可信区间83.21%-83.25%）。东部地区抗-HAV IgG的年龄别阳性率（96.79%，95%可信区间96.78%-96.80%）高于中部地区（86.66%，95%可信区间86.65%-86.67%）和西部地区（91.96%，95%可信区间91.95%-91.97%）。山东省普通人群抗-HAV IgG阳性率较高，但中青年成人相对较低。除儿童常规接种甲型肝炎疫苗外，山东省应加强对中青年成人尤其是中西部地区甲型肝炎的防控工作。
