Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan, Republic of China.
J Nat Prod. 2010 Jun 25;73(6):1170-2. doi: 10.1021/np9008317.
The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 0.1 mg/kg 1 significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Catalpol enhanced the uptake of radioactive glucose in the isolated soleus muscle of STZ-diabetic rats in a concentration-related manner. Moreover, an effect by 1 was established on glycogen incorporation in hepatocytes isolated from STZ-diabetic rats. Catalpol was found to increase glycogen synthesis in STZ-diabetic rats. These results suggest that 1 can increase glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
从地黄根中分离得到的梓醇（1）对链脲佐菌素诱导的糖尿病大鼠（STZ 糖尿病大鼠）具有抗高血糖作用，代表胰岛素依赖型糖尿病。1 在 STZ 糖尿病大鼠中表现出剂量依赖性的抗高血糖活性的静脉推注。有效剂量 0.1mg/kg 的 1 可显著减弱正常大鼠静脉葡萄糖挑战试验引起的血糖升高。梓醇以浓度相关的方式增强 STZ 糖尿病大鼠分离的比目鱼肌中放射性葡萄糖的摄取。此外，1 对 STZ 糖尿病大鼠分离的肝细胞中的糖原掺入也有作用。发现梓醇可增加 STZ 糖尿病大鼠的糖原合成。这些结果表明，1 可增加葡萄糖的利用，降低缺乏胰岛素的糖尿病大鼠的血糖。
