Hsu Feng-Lin, Liu I-Min, Kuo Daih-Huang, Chen Wang-Chuan, Su Hui-Chen, Cheng Juei-Tang
Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei City, Taiwan 110-31.
J Nat Prod. 2003 Jun;66(6):788-92. doi: 10.1021/np0203887.
The antihyperglycemic action of puerarin, purified from the roots of Pueraria lobata, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection of puerarin decreased the plasma glucose concentrations in a dose-dependent manner in STZ-diabetic rats. Similar treatment with puerarin also decreased the plasma glucose in normal rats, although the effect was not as great as that in STZ-diabetic rats. Puerarin at the effective dose (15.0 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, puerarin enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of puerarin in STZ-diabetic rats for 3 days. These results suggest that puerarin can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
从葛根根中纯化得到的葛根素对链脲佐菌素诱导的糖尿病大鼠（STZ糖尿病大鼠）的降血糖作用进行了研究。静脉推注葛根素可使STZ糖尿病大鼠的血浆葡萄糖浓度呈剂量依赖性降低。用葛根素进行类似处理也可降低正常大鼠的血浆葡萄糖，尽管其效果不如STZ糖尿病大鼠明显。有效剂量（15.0mg/kg）的葛根素可显著减轻正常大鼠静脉葡萄糖激发试验诱导的血浆葡萄糖升高。在STZ糖尿病大鼠的离体比目鱼肌中，葛根素以浓度依赖性方式增强放射性葡萄糖的摄取。此外，在STZ糖尿病大鼠中，连续3天静脉注射葛根素后，比目鱼肌中葡萄糖转运蛋白4亚型（GLUT4）的mRNA和蛋白质水平升高。这些结果表明，葛根素可增加糖尿病大鼠（缺乏胰岛素）的葡萄糖利用以降低血浆葡萄糖。
