Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
Nano Lett. 2010 Jul 14;10(7):2690-3. doi: 10.1021/nl101640k.
Novel, responsive liposomes are introduced, assembled from DNA-programmed lipids allowing sequence selective manipulation of nanoscale morphology. Short, single-stranded DNA sequences form polar head groups conjugated to hydrophobic tails. The morphology of the resulting lipid aggregates depends on sterics and electronics in the polar head groups and, therefore, is dependent on the DNA hybridization state. The programmability, specificity, and reversibility of the switchable system are demonstrated via dynamic light scattering, transmission electron microscopy, and fluorescence microscopy.
新型响应性脂质体的组装，是由 DNA 编程脂质组成，允许对纳米级形态进行序列选择性操作。短的单链 DNA 序列形成极性头基团，与疏水头相连。所得脂质体聚集物的形态取决于极性头基团的空间位阻和电子性质，因此依赖于 DNA 杂交状态。通过动态光散射、透射电子显微镜和荧光显微镜证明了该可切换系统的可编程性、特异性和可逆性。
