Benalla Wafaa, Bellahcen Saïd, Bnouham Mohamed
Laboratoire de Physiologie et Ethnopharmacologie, Département de Biologie, 60000 Oujda, Morocco.
Curr Diabetes Rev. 2010 Jul;6(4):247-54. doi: 10.2174/157339910791658826.
The aim of this study is to collate all available data on antidiabetic plants that inhibit alpha glucosidase, reported mainly by Medline (PubMed) these last years. In the present study, interest is focused on experimental researches conducted on hypoglycemic plants particularly those which show alpha glucosidase inhibitor activity alongside bioactive components. This study describes 47 species that belong to 29 families. The plant families, which enclose the species, studied most as inhibitors of alphaglucosidase, are Fabaceae (6 species.), Crassulaceae (3 species), Hippocrateacaea (3 species), Lamiaceae (3 species), and Myrtaceae (3 species), with most studied species being Salacia reticulata (Hippocrateaceae) and Morus alba (Moraceae). The study also covers natural products (active natural components and crude extracts) isolated from the medicinal plants which inhibit alpha glucosidase as reported this last decade. Many kinds of these isolated natural products show strong activity such as, Alkaloids, stilbenoids (polyphenol), triterpene, acids (chlorogenic acid, betulinic acid, syringic acid, vanillic acid, bartogenic acid, oleanolic acid, dehydrotrametenolic acid, corosolic acid, ellagic acid, ursolic acid, gallic acid), phytosterol, myoinositol, flavonoids, Flavonolignans, anthraquinones, anthrones, and xanthones, Feruloylglucosides, flavanone glucosides, acetophenone glucosides, glucopyranoside derivatives, genine derivatives, flavonol, anthocyanin and others.
本研究的目的是整理近年来主要由Medline（PubMed）报道的关于抑制α-葡萄糖苷酶的抗糖尿病植物的所有可用数据。在本研究中，重点关注对降血糖植物进行的实验研究，特别是那些除生物活性成分外还具有α-葡萄糖苷酶抑制活性的植物。本研究描述了属于29个科的47个物种。作为α-葡萄糖苷酶抑制剂研究最多的包含这些物种的植物科有豆科（6种）、景天科（3种）、希藤科（3种）、唇形科（3种）和桃金娘科（3种），研究最多的物种是网脉五层龙（希藤科）和桑（桑科）。该研究还涵盖了过去十年报道的从抑制α-葡萄糖苷酶的药用植物中分离出的天然产物（活性天然成分和粗提物）。这些分离出的天然产物中有许多显示出强大的活性，如生物碱、芪类化合物（多酚）、三萜、酸（绿原酸、桦木酸、丁香酸、香草酸、巴托格酸、齐墩果酸、脱氢栓菌酸、熊果酸、鞣花酸、乌索酸、没食子酸）、植物甾醇、肌醇、黄酮类化合物、黄酮木脂素、蒽醌、蒽酮和呫吨酮、阿魏酰葡萄糖苷、黄烷酮葡萄糖苷、苯乙酮葡萄糖苷、葡萄糖吡喃糖苷衍生物、配基衍生物、黄酮醇、花青素等。
