科他那醇，一种具有硫代糖硫酸鏻结构的强效α-葡萄糖苷酶抑制剂，源自抗糖尿病阿育吠陀药物网状叶海檀木。
Kotalanol, a potent alpha-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata.
作者信息
Yoshikawa M, Murakami T, Yashiro K, Matsuda H
机构信息
Kyoto Pharmaceutical University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1339-40. doi: 10.1248/cpb.46.1339.
A potent natural alpha-glucosidase inhibitor called kotalanol has been isolated from an antidiabetic traditional Ayurvedic medicine, the roots and stems of Salacia reticulata Wight, through bioassay-guided separation. The structure of kotalanol was elucidated on the basis of chemical and physicochemical evidence to be the inner salt comprised of 1-deoxyheptosyl-3-sulfate anion and 1-deoxy-4-thio-D-arabinofuranosyl sulfonium cation. Kotalanol was found to show more potent inhibitory activity against sucrase than salacinol and acarbose.
一种名为柯他烷醇的强效天然α-葡萄糖苷酶抑制剂已通过生物活性导向分离法，从一种抗糖尿病的传统阿育吠陀药物——网状刺桐（Salacia reticulata Wight）的根和茎中分离出来。基于化学和物理化学证据，柯他烷醇的结构被确认为是由1-脱氧庚糖基-3-硫酸根阴离子和1-脱氧-4-硫代-D-阿拉伯呋喃糖基锍阳离子组成的内盐。研究发现，柯他烷醇对蔗糖酶的抑制活性比沙拉醇和阿卡波糖更强。
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