Corona G, Rastrelli G, Boddi V, Monami M, Melani C, Balzi D, Sforza A, Forti G, Mannucci E, Maggi M
Andrology Unit and Endocrinology, Department of Clinical Physiopathology, University of Florence, Florence, Italy.
Int J Androl. 2011 Jun;34(3):217-24. doi: 10.1111/j.1365-2605.2010.01076.x.
The physiological role of prolactin (PRL) in men is not completely clarified. We previously reported that in subjects consulting for sexual dysfunction, lower PRL plasma levels were associated with worse lipid and glycaemic profile, as well as with a higher prevalence of metabolic syndrome and arteriogenic erectile dysfunction (ED). The aim of this study was to assess possible associations between PRL levels and incident major cardiovascular events (MACE) in subjects with ED. When only subjects without pathological hyperprolactinaemia (PRL < 735 mU/L or 35 ng/mL) and pituitary diseases were considered, both unadjusted and adjusted analyses showed a significantly lower incidence of MACE in subjects with PRL levels in the highest PRL quintile (246-735 mU/L or 12-35 ng/mL) when compared with the rest of the sample. In particular, the risk of MACE was reduced by 5% (1-9%; p = 0.03) for each 10 ng/mL increment of PRL. Conversely, comparing patients with hyperprolactinaemia with matched controls, no significant difference was detected between cases and controls in MACE. In subjects at high risk for cardiovascular diseases, such as those with ED, a relatively high PRL plasma level is associated with an overall decreased chance of MACE, independently from other known risk factors.
催乳素（PRL）在男性体内的生理作用尚未完全阐明。我们之前报道过，在因性功能障碍前来咨询的受试者中，较低的PRL血浆水平与较差的脂质和血糖状况相关，同时也与代谢综合征和动脉源性勃起功能障碍（ED）的较高患病率相关。本研究的目的是评估ED患者中PRL水平与主要心血管事件（MACE）发生率之间的可能关联。当仅考虑无病理性高催乳素血症（PRL < 735 mU/L或35 ng/mL）且无垂体疾病的受试者时，未调整和调整后的分析均显示，与样本中的其他受试者相比，PRL水平处于最高五分位数（246 - 735 mU/L或12 - 35 ng/mL）的受试者发生MACE的发生率显著更低。特别是，PRL每增加10 ng/mL，MACE风险降低5%（1 - 9%；p = 0.03）。相反，将高催乳素血症患者与匹配的对照组进行比较时，病例组和对照组在MACE方面未检测到显著差异。在心血管疾病高危受试者中，如患有ED的受试者，相对较高的PRL血浆水平与MACE总体发生几率降低相关，且独立于其他已知风险因素。
