Immunology Section, Faculty of Medicine, University of Bari, Bari, Italy.
Proc Nutr Soc. 2010 Aug;69(3):279-85. doi: 10.1017/S0029665110000121. Epub 2010 Jun 4.
It is well known that the consumption of dietary polyphenols leads to beneficial effects for human health as in the case of prevention and/or attenuation of cardiovascular, inflammatory, neurodegenerative and neoplastic diseases. This review summarizes the role of polyphenols from red wine in the immune function. In particular, using healthy human peripheral blood mononuclear cells, we have demonstrated the in vitro ability of Negroamaro, an Italian red wine, to induce the release of nitric oxide and both pro-inflammatory and anti-inflammatory cytokines, thus leading to the maintenance of the immmune homeostasis in the host. All these effects were abrogated by deprivation of polyphenols from red wine samples. We have also provided evidence that Negromaro polyphenols are able to activate extracellular regulated kinase and p38 kinase and switch off the NF-kappaB pathway via an increased expression with time of the IkappaBalpha phosphorylated form. These mechanisms may represent key molecular events leading to inhibition of the pro-inflammatory cascade and atherogenesis. In conclusion, according to the current literature and our own data, moderate consumption of red wine seems to be protective for the host in the prevention of several diseases, even including aged-related diseases by virtue of its immunomodulating properties.
众所周知，饮食多酚的摄入对人类健康有益，如预防和/或减轻心血管、炎症、神经退行性和肿瘤疾病。这篇综述总结了红葡萄酒中多酚对免疫功能的作用。特别是，我们使用健康人的外周血单核细胞，证明了意大利红葡萄酒 Negroamaro 具有体外诱导一氧化氮和促炎及抗炎细胞因子释放的能力，从而维持宿主的免疫稳态。所有这些作用都被剥夺红葡萄酒样品中的多酚所消除。我们还提供了证据表明 Negroamaro 多酚能够通过增加 IkappaBalpha 磷酸化形式的表达，激活细胞外调节激酶和 p38 激酶，并通过时间推移关闭 NF-kappaB 途径。这些机制可能代表抑制促炎级联反应和动脉粥样硬化形成的关键分子事件。总之，根据目前的文献和我们自己的数据，适量饮用红葡萄酒似乎对宿主具有保护作用，可预防多种疾病，甚至包括与年龄相关的疾病，这要归功于其免疫调节特性。
