细胞质铁硫簇组装（CIA）系统：因素、机制及与细胞铁调节的相关性。
Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation.
机构信息
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612.
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612.
出版信息
J Biol Chem. 2010 Aug 27;285(35):26745-26751. doi: 10.1074/jbc.R110.122218. Epub 2010 Jun 3.
Abstract
FeS cluster biogenesis is an essential process in virtually all forms of life. Complex protein machineries that are conserved from bacteria through higher eukaryotes facilitate assembly of the FeS cofactor in proteins. In the last several years, significant strides have been made in our understanding of FeS cluster assembly and the functional overlap of this process with cellular iron homeostasis. This minireview summarizes the present understanding of the cytosolic iron-sulfur cluster assembly (CIA) system in eukaryotes, with a focus on information gained from studies in budding yeast and mammalian systems.
摘要
铁硫簇生物发生是几乎所有生命形式的必要过程。从细菌到高等真核生物都保守的复杂蛋白质机器促进了蛋白质中 FeS 辅因子的组装。在过去的几年中，我们对 FeS 簇组装的理解以及该过程与细胞铁稳态的功能重叠取得了重大进展。这篇综述总结了真核生物细胞溶质铁硫簇组装（CIA）系统的现有认识，重点介绍了从芽殖酵母和哺乳动物系统研究中获得的信息。
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