He Chun-Nian, Peng Yong, Xu Li-Jia, Liu Zheng-An, Gu Jing, Zhong Ai-Guo, Xiao Pei-Gen
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College.
Chem Pharm Bull (Tokyo). 2010 Jun;58(6):843-7. doi: 10.1248/cpb.58.843.
Three new oligostilbenes, trans-suffruticosol D (1), cis-suffruticosol D (2), and cis-gnetin H (7), were isolated along with the eight known stilbenes, trans-resveratrol (3), trans-epsilon-viniferin (4), cis-epsilon-viniferin (5), gnetin H (6), suffruticosol A (8), suffruticosol B (9), suffruticosol C (10), and cis-ampelopsin E (11) from the seeds of Paeonia suffruticosa. Compounds 3-6 were isolated for the first time from this plant species, and compound 11 was isolated for the first time from the genus Paeonia. The structures of the new compounds were elucidated based on spectral analyses, including 1D and 2D NMR experiments. The absolute configuration of compound 1 was determined by quantum chemical calculation of the electronic circular dichroism and comparison with the experimental circular dichroism spectrum.
从牡丹籽中分离出三种新的低聚芪，即反式紫铆醇D（1）、顺式紫铆醇D（2）和顺式买麻藤素H（7），以及八种已知的芪类化合物，反式白藜芦醇（3）、反式ε-葡萄素（4）、顺式ε-葡萄素（5）、买麻藤素H（6）、紫铆醇A（8）、紫铆醇B（9）、紫铆醇C（10）和顺式蛇葡萄素E（11）。化合物3 - 6首次从该植物物种中分离得到，化合物11首次从芍药属中分离得到。基于光谱分析，包括一维和二维核磁共振实验，阐明了新化合物的结构。通过电子圆二色性的量子化学计算并与实验圆二色光谱进行比较，确定了化合物1的绝对构型。
