Chemical Engineering & Pharmaceutical College, Henan University of Science and Technology, Research Center on Wild Natural Resources of FUNIU Mountain, Luoyang 471023, China.
Molecules. 2014 Nov 26;19(12):19549-56. doi: 10.3390/molecules191219549.
In the course of screening natural products for antibacterial activities, a total acetone extract of the seed cake of Paeonia rockii showed significant effects against bacterial strains. Bioactivity-guided fractionation of the EtOAc-soluble fraction of the total acetone extract resulted in the isolation and identification of five resveratrol trimers, including rockiiol C (1), gnetin H (2), suffruticosol A (3), suffruticosol B (4) and suffruticosol C (5). The relative configuration of these compounds was elucidated mainly by comprehensive 1D and 2D-NMR experiments. Compound 1 was a new compound. All isolated compounds exhibited strong antibacterial activities against Gram-positive bacteria.
在筛选具有抗菌活性的天然产物的过程中，芍药籽饼的全丙酮提取物对细菌菌株表现出显著的抑制作用。对全丙酮提取物的 EtOAc 可溶部分进行生物活性导向分离，得到了五个白藜三聚体，包括芍药醇 C（1）、五味子素 H（2）、金缕梅醇 A（3）、金缕梅醇 B（4）和金缕梅醇 C（5）。这些化合物的相对构型主要通过综合 1D 和 2D-NMR 实验来阐明。化合物 1 为新化合物。所有分离得到的化合物均表现出对革兰氏阳性菌的强烈抗菌活性。
